4mkt A 1.618 BS01 ZN A 1 H295 H299 E318 H293 H297 E316 E271 H295 E296 H299 E318 D375 Y383 E269 H293 E294 H297 E316 D373 Y381 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 P09960 24591641 701 IVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 4mkt A 1.618 BS02 28T A 1 Q136 Y267 G268 M270 E271 E318 Y378 Y383 R563 K565 Q134 Y265 G266 M268 E269 E316 Y376 Y381 R561 K563 E271 H295 E296 H299 E318 D375 Y383 E269 H293 E294 H297 E316 D373 Y381 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 P09960 24591641 702 IVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 4mkt A 1.618 BS03 1V6 A 1 A137 Y267 W311 F314 F362 K364 L365 V367 P374 Y378 V381 P382 A135 Y265 W309 F312 F360 K362 L363 V365 P372 Y376 V379 P380 E271 H295 E296 H299 E318 D375 Y383 E269 H293 E294 H297 E316 D373 Y381 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 Ki=2.3uM IC50=12400nM, Kd=130nM, Ki=360nM P09960 24591641 703 IVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD