4mjo A 2.4 BS01 2C1 A 1 V17 M18 G21 R22 R25 G26 G28 L30 T31 V9 M10 G13 R14 R17 G18 G20 L22 T23 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM -logKd/Ki=6.22, Kd=0.60uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 4mjo B 2.4 BS01 2C1 B 1 M18 G21 R22 R25 G26 G28 L30 T31 M10 G13 R14 R17 G18 G20 L22 T23 D74 E97 E98 D118 L120 D121 E280 D56 E79 E80 D100 L102 D103 E262 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 4mjo C 2.4 BS01 2C1 C 1 M18 G21 R22 R25 G26 G28 L30 T31 M177 M10 G13 R14 R17 G18 G20 L22 T23 M159 D74 E97 E98 D118 L120 D121 E280 D56 E79 E80 D100 L102 D103 E262 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM -logKd/Ki=6.22, Kd=0.60uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 4mjo D 2.4 BS01 2C1 D 1 V17 M18 E20 G21 R22 R25 G26 G28 L30 T31 V9 M10 E12 G13 R14 R17 G18 G20 L22 T23 D74 E97 E98 D118 L120 D121 E280 D57 E80 E81 D101 L103 D104 E263 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 4mjo E 2.4 BS01 2C1 E 1 M18 G21 R22 R25 G26 G28 L30 T31 M177 M10 G13 R14 R17 G18 G20 L22 T23 M161 D74 E97 E98 D118 L120 D121 E280 D58 E81 E82 D102 L104 D105 E264 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 4mjo F 2.4 BS01 2C1 F 1 V17 M18 G21 R22 R25 G26 G28 L30 T31 M177 V9 M10 G13 R14 R17 G18 G20 L22 T23 M159 D74 E97 E98 D118 L120 D121 E280 D56 E79 E80 D100 L102 D103 E262 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 4mjo G 2.4 BS01 2C1 G 1 V17 M18 G21 R22 R25 G26 G28 L30 T31 V9 M10 G13 R14 R17 G18 G20 L22 T23 D74 E97 E98 D118 L120 D121 E280 D56 E79 E80 D100 L102 D103 E262 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS 4mjo H 2.4 BS01 2C1 H 1 V17 M18 G21 R22 R25 G26 G28 L30 T31 V160 V9 M10 G13 R14 R17 G18 G20 L22 T23 V142 D74 E97 E98 D118 L120 D121 E280 D56 E79 E80 D100 L102 D103 E262 3.1.3.11 0000122,0005515,0005615,0005634,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0031667,0032869,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0061629,0070062,0071286,0071320,0071466,0071475,0071477,0097403,1904628 Kd=0.6uM IC50=80nM P09467 24128068 401 DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS