4lop A 2.049 BS01 peptide K 0 N26 S28 N24 S26 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 384 ~ 412 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop A 2.049 BS02 peptide M 0 G110 Q120 K121 L122 H126 F129 V158 N159 E160 C162 L217 T218 L222 V273 I275 G276 A277 N278 G108 Q118 K119 L120 H124 F127 V156 N157 E158 C160 L215 T216 L220 V271 I273 G274 A275 N276 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 385 ~ 411 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop A 2.049 BS03 SB4 A 1 V38 A51 L104 V105 T106 L108 M109 D112 L167 V36 A49 L102 V103 T104 L106 M107 D110 L165 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 -logKd/Ki=8.15, Kd=0.007uM P47811 24037507 401 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop B 2.049 BS01 peptide L 0 G110 A111 I116 Q120 L122 D125 H126 N159 E160 D161 C162 L217 T218 V273 I275 G276 A277 N278 G107 A108 I113 Q117 L119 D122 H123 N156 E157 D158 C159 L214 T215 V270 I272 G273 A274 N275 D150 K152 N155 D168 T185 D147 K149 N152 D165 T182 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 384 ~ 412 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop B 2.049 BS02 SB4 B 1 V38 A51 K53 L104 T106 M109 D112 L167 V35 A48 K50 L101 T103 M106 D109 L164 D150 K152 N155 D168 T185 D147 K149 N152 D165 T182 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 401 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop C 2.049 BS01 peptide K 0 G110 A111 I116 Q120 K121 L122 H126 N159 E160 C162 L217 T218 R220 V273 I275 G276 A277 N278 G108 A109 I114 Q118 K119 L120 H124 N157 E158 C160 L215 T216 R218 V261 I263 G264 A265 N266 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 384 ~ 412 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop C 2.049 BS02 SB4 C 1 V38 A51 K53 L104 V105 T106 M109 D112 L167 V36 A49 K51 L102 V103 T104 M107 D110 L165 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 401 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop D 2.049 BS01 peptide L 0 N26 S28 N24 S26 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 384 ~ 412 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop D 2.049 BS02 peptide N 0 G110 A111 I116 Q120 L122 T123 H126 N159 E160 L217 T218 L222 V273 I275 G276 A277 N278 G108 A109 I114 Q118 L120 T121 H124 N157 E158 L215 T216 L220 V271 I273 G274 A275 N276 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 384 ~ 411 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 4lop D 2.049 BS03 SB4 D 1 V38 A51 L104 V105 T106 M109 D112 V36 A49 L102 V103 T104 M107 D110 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 24037507 401 QERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL