4lmn A 2.8 BS01 ANP A 1 A76 G77 V82 A95 K97 M143 E144 M146 Q153 K192 S194 N195 L197 D208 A16 G17 V22 A35 K37 M83 E84 M86 Q93 K132 S134 N135 L137 D148 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 23934108 501 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 4lmn A 2.8 BS02 MG A 1 N195 D208 N135 D148 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 23934108 502 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 4lmn A 2.8 BS03 EUI A 1 K97 L118 V127 I141 M143 D190 D208 F209 S212 L215 K37 L58 V67 I81 M83 D130 D148 F149 S152 L155 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=10.30, Ki=0.05nM IC50=4.2nM Q02750 23934108 503 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN