4l2o A 1.937 BS01 NAD A 1 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 G211 C243 H289 E333 F335 F401 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 G211 C243 H289 E333 F335 F401 N114 K137 E209 C243 E333 Y412 N114 K137 E209 C243 E333 Y412 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 P30838 505 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSP 4l2o A 1.937 BS02 1DD A 1 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 H413 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 H413 N114 K137 E209 C243 E333 Y412 N114 K137 E209 C243 E333 Y412 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 Ki=200nM, IC50=200nM P30838 506 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSP 4l2o B 1.937 BS01 NAD B 1 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 C243 H289 E333 F335 F401 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 C243 H289 E333 F335 F401 N114 K137 E209 C243 E333 Y412 N114 K137 E209 C243 E333 Y412 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 P30838 503 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o B 1.937 BS02 1DD B 1 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 T395 F401 N114 K137 E209 C243 E333 Y412 N114 K137 E209 C243 E333 Y412 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 Ki=200nM, IC50=200nM P30838 504 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o E 1.937 BS01 NAD E 1 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 C243 H289 E333 F335 F401 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 C243 H289 E333 F335 F401 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 P30838 503 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o E 1.937 BS02 1DD E 1 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 F401 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 F401 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 Ki=200nM, IC50=200nM P30838 504 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o G 1.937 BS01 NAD G 1 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 C243 H289 E333 F335 F401 T112 W113 N114 L119 E140 V169 T186 G187 S188 V191 E209 L210 C243 H289 E333 F335 F401 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 P30838 504 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA 4l2o G 1.937 BS02 1DD G 1 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 F401 H413 E61 Y65 Y115 N118 L119 M237 C243 I391 I394 F401 H413 1.2.1.5 0004028,0004029,0004030,0005515,0005615,0005737,0005783,0005829,0005886,0006081,0006629,0006805,0008106,0016020,0016491,0016620,0018479 Ki=200nM, IC50=200nM P30838 505 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPA