4kwf A 2.31 BS01 3AK A 1 F170 M174 W177 E268 C301 C302 C303 D457 F459 F465 F164 M168 W171 E262 C295 C296 C297 D451 F453 F459 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=15uM -logKd/Ki=4.82, Ki=15uM Ki=34000nM, IC50=82000nM P05091 24444054 601 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 4kwf B 2.31 BS01 3AK B 1 F170 L173 M174 E268 C301 C302 C303 L427 F459 F465 F164 L167 M168 E262 C295 C296 C297 L421 F453 F459 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=15uM Ki=34000nM, IC50=82000nM P05091 24444054 601 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 4kwf E 2.31 BS01 3AK E 1 F170 L173 W177 E268 F296 C301 C302 C303 D457 F459 F465 F164 L167 W171 E262 F290 C295 C296 C297 D451 F453 F459 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=15uM Ki=34000nM, IC50=82000nM P05091 24444054 601 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS 4kwf H 2.31 BS01 3AK H 1 F170 M174 W177 F296 C301 C302 C303 D457 F459 F465 F164 M168 W171 F290 C295 C296 C297 D451 F453 F459 N169 K192 E268 C302 E399 E476 N163 K186 E262 C296 E393 E470 1.2.1.3 0004029,0004030,0005739,0005759,0005975,0006066,0006068,0008957,0009055,0016491,0016620,0018937,0046185,0051287,0070062,0106435,1903179,1905627 Ki=15uM Ki=34000nM, IC50=82000nM P05091 24444054 601 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS