4kio A 2.18 BS01 G5K A 1 I369 A389 F435 F437 M438 G441 C442 L489 I15 A32 F72 F74 M75 G78 C79 L126 D482 A484 R486 N487 D500 P521 D119 A121 R123 N124 D137 P142 2.7.10.2 0004672,0004713,0004715,0005524,0006468 ic50=0.5uM -logKd/Ki=6.30, IC50=0.501uM Q08881 23935099 701 GSVIDPSELTFVQEIGSGLVHLGYWLNKDKVAIKTIEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESG 4kio B 2.18 BS01 G5K B 1 I369 A389 F435 F437 M438 E439 G441 C442 L489 I15 A32 F71 F73 M74 E75 G77 C78 L125 D482 A484 R486 N487 D500 P521 D118 A120 R122 N123 D136 P141 2.7.10.2 0004672,0004713,0004715,0005524,0006468 ic50=0.5uM Q08881 23935099 701 GSVIDPSELTFVQEIGSGLVHLGYWLNKDKVAIKTIEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESG 4kio C 2.18 BS01 G6K C 1 I369 A389 F435 F437 M438 G441 C442 L489 I15 A35 F81 F83 M84 G87 C88 L135 D482 A484 R486 N487 D500 P521 D128 A130 R132 N133 D146 P152 2.7.10.2 0004672,0004713,0004715,0005524,0006468 Q08881 23935099 701 GSVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL 4kio C 2.18 BS02 G5K C 1 I369 A389 F435 F437 M438 G441 C442 L489 I15 A35 F81 F83 M84 G87 C88 L135 D482 A484 R486 N487 D500 P521 D128 A130 R132 N133 D146 P152 2.7.10.2 0004672,0004713,0004715,0005524,0006468 ic50=0.5uM Q08881 23935099 702 GSVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL 4kio D 2.18 BS01 G6K D 1 I369 A389 F435 F437 M438 E439 G441 C442 L489 I15 A35 F76 F78 M79 E80 G82 C83 L130 D482 A484 R486 N487 D500 P521 D123 A125 R127 N128 D141 P145 2.7.10.2 0004672,0004713,0004715,0005524,0006468 Q08881 23935099 701 GSVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTISEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES