4kcg A 2.09 BS01 1QC A 1 E53 V55 L82 M85 Y86 P89 Q97 D133 F137 S144 Y204 E34 V36 L52 M55 Y56 P59 Q67 D103 F107 S114 Y174 E53 R128 E34 R98 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 -logKd/Ki=8.30, IC50=5nM IC50=4.9nM, Ki=0.500000nM P27707 24567448 301 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4kcg A 2.09 BS02 UDP A 1 A31 G33 K34 S35 T36 R188 R192 D241 F242 A12 G14 K15 S16 T17 R158 R162 D211 F212 E53 R128 E34 R98 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 24567448 302 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4kcg B 2.09 BS01 1QC B 1 E53 Y86 F96 Q97 D133 F137 P201 Y204 E34 Y56 F66 Q67 D103 F107 P171 Y174 E53 R128 E34 R98 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 IC50=4.9nM, Ki=0.500000nM P27707 24567448 301 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4kcg B 2.09 BS02 UDP B 1 A31 A32 G33 K34 S35 T36 R188 R192 D241 F242 K243 A12 A13 G14 K15 S16 T17 R158 R162 D211 F212 K213 E53 R128 E34 R98 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 24567448 302 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL