4k4b A 1.9 BS01 UOQ A 1 D43 S44 K47 P49 E95 D43 S44 K47 P49 E95 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b A 1.9 BS02 UOQ A 2 Q48 P49 H54 G55 H89 V90 R91 Q48 P49 H54 G55 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b A 1.9 BS03 UOQ B 2 L12 G16 V21 E63 S67 G82 L136 L12 G16 V21 E63 S67 G82 L136 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 202 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b A 1.9 BS04 UOQ C 1 H106 G108 S109 R110 H111 H106 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b B 1.9 BS01 UOQ A 1 A14 M15 E17 G18 N19 A14 M15 E17 G18 N19 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b B 1.9 BS02 UOQ A 2 L12 M15 G16 V21 F28 S67 V81 G82 L136 L12 M15 G16 V21 F28 S67 V81 G82 L136 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b B 1.9 BS03 UOQ B 1 G108 S109 R110 H111 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b B 1.9 BS04 UOQ B 2 Q48 P49 H54 G55 H89 V90 R91 Q48 P49 H54 G55 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 202 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b C 1.9 BS01 UOQ A 2 H106 G108 S109 R110 H111 H106 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b C 1.9 BS02 UOQ B 1 L12 M15 V21 S67 V68 V81 L12 M15 V21 S67 V68 V81 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b C 1.9 BS03 UOQ C 1 Q48 P49 H54 G55 H89 V90 R91 Q48 P49 H54 G55 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b C 1.9 BS04 UOQ D 1 M15 G18 N19 M15 G18 N19 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 501 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b D 1.9 BS01 UOQ B 1 Q48 P49 H54 G55 H89 V90 R91 Q48 P49 H54 G55 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b D 1.9 BS02 UOQ B 2 H106 G108 S109 R110 H111 H106 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 202 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b D 1.9 BS03 UOQ C 1 S67 G82 S67 G82 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b D 1.9 BS04 UOQ D 1 S44 K47 S44 K47 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 501 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b E 1.9 BS01 UOQ E 1 V42 D43 S44 P49 E95 G96 V42 D43 S44 P49 E95 G96 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b E 1.9 BS02 UOQ E 2 H106 G108 S109 R110 H111 H106 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b E 1.9 BS03 UOQ E 3 Q48 P49 H54 G55 H89 V90 R91 Q48 P49 H54 G55 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 204 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b E 1.9 BS04 UOQ H 3 V21 E63 S67 V21 E63 S67 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b F 1.9 BS01 UOQ E 1 A11 M15 G18 N19 A11 M15 G18 N19 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b F 1.9 BS02 UOQ E 3 L12 E63 S67 V68 V81 G82 L12 E63 S67 V68 V81 G82 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 204 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b F 1.9 BS03 UOQ F 1 H106 G108 S109 R110 H111 H106 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b F 1.9 BS04 UOQ H 3 Q48 P49 H54 G55 H89 V90 R91 Q48 P49 H54 G55 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b G 1.9 BS01 UOQ E 2 Q48 P49 H54 G55 H89 V90 R91 Q48 P49 H54 G55 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b G 1.9 BS02 UOQ E 3 H106 G108 S109 R110 H111 H106 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 P77781 25010423 204 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b G 1.9 BS03 UOQ F 1 M15 E63 S67 V81 G82 M15 E63 S67 V81 G82 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b G 1.9 BS04 UOQ H 1 S44 K47 P49 S44 K47 P49 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b G 1.9 BS05 UOQ H 2 A11 A14 G18 N19 A11 A14 G18 N19 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 P77781 25010423 202 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b H 1.9 BS01 UOQ E 2 L12 M15 F28 S67 V68 G82 L12 M15 F28 S67 V68 G82 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b H 1.9 BS02 UOQ F 1 Q48 P49 H54 H89 V90 R91 Q48 P49 H54 H89 V90 R91 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b H 1.9 BS03 UOQ H 1 A14 G18 N19 A14 G18 N19 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 201 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b H 1.9 BS04 UOQ H 2 D43 S44 K47 D43 S44 K47 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 202 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL 4k4b H 1.9 BS05 UOQ H 3 H106 G108 S109 R110 H111 H106 G108 S109 R110 H111 3.1.2.28 0005829,0009234,0016289,0016787,0016790,0061522 Ki=12.2uM P77781 25010423 203 MIWKRKITLEALNAMGEGNMVGFLDIRFEHIGDDTLEATMPVDSRTKQPFGLLHGGASVVLAESIGSVAGYLCTEGEQKVVGLEINANHVRSAREGRVRGVCKPLHLGSRHQVWQIEIFDEKGRLCCSSRLTTAIL