4k42 A 2.9 BS01 ADP A 1 G13 S14 G15 K18 G156 D157 G182 K213 E214 G302 M305 Y306 G9 S10 G11 K14 G142 D143 G168 K199 E200 G288 M291 Y292 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25047814 402 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 4k42 A 2.9 BS02 NWM A 1 Y143 G168 Y169 I345 M355 Y129 G154 Y155 I331 M341 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 -logKd/Ki=6.55, Kd=285nM P68135 25047814 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 4k42 B 2.9 BS01 ADP B 1 S14 G15 L16 K18 G156 D157 K213 E214 G301 G302 M305 Y306 S10 G11 L12 K14 G143 D144 K200 E201 G288 G289 M292 Y293 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25047814 402 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 4k42 B 2.9 BS02 NWM B 1 Y143 G146 G168 Y169 I345 L349 M355 Y130 G133 G155 Y156 I332 L336 M342 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25047814 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 4k42 C 2.9 BS01 ADP C 1 G13 S14 G15 L16 K18 G156 D157 G182 R210 K213 E214 G302 M305 Y306 G9 S10 G11 L12 K14 G143 D144 G169 R197 K200 E201 G289 M292 Y293 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25047814 402 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 4k42 C 2.9 BS02 NWM C 1 Y143 G146 G168 Y169 I345 M355 Y130 G133 G155 Y156 I332 M342 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25047814 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 4k42 D 2.9 BS01 ADP D 1 S14 G15 K18 G156 D157 K213 E214 G301 G302 M305 Y306 S10 G11 K14 G142 D143 K199 E200 G287 G288 M291 Y292 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25047814 402 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC 4k42 D 2.9 BS02 NWM D 1 Y143 G146 G168 Y169 I345 L349 M355 Y129 G132 G154 Y155 I331 L335 M341 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25047814 403 TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC