4jnk A 1.896 BS01 NAI A 1 G28 A29 V30 D51 V52 I53 T94 A95 G96 A97 R98 V135 N137 H192 I251 G28 A29 V30 D51 V52 I53 T94 A95 G96 A97 R98 V130 N132 H187 I246 R105 D165 R168 H192 R100 D160 R163 H187 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 23628333 801 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARSRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4jnk A 1.896 BS02 ZHK A 1 R98 R105 L108 N137 P138 D140 E191 H192 D194 Y238 R98 R100 L103 N132 P133 D135 E186 H187 D189 Y233 R105 D165 R168 H192 R100 D160 R163 H187 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 Kd=5.1uM IC50=750nM, Kd=5100nM P00338 23628333 803 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARSRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4jnk B 1.896 BS01 NAI B 1 G28 A29 V30 D51 V52 I53 K56 T94 A95 A97 R98 I119 V135 N137 H192 I251 G28 A29 V30 D51 V52 I53 K56 T94 A95 A97 R98 I119 V135 N137 H192 I251 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 23628333 801 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4jnk C 1.896 BS01 NAI C 1 G28 V30 D51 V52 I53 T94 A95 R98 I119 V135 N137 H192 I251 G28 V30 D51 V52 I53 T94 A95 R98 I119 V135 N137 H192 I251 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 23628333 801 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4jnk C 1.896 BS02 ZHK C 1 R105 L108 N137 P138 D140 E191 H192 Y238 R105 L108 N137 P138 D140 E191 H192 Y238 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 Kd=5.1uM IC50=750nM, Kd=5100nM P00338 23628333 803 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4jnk D 1.896 BS01 NAI D 1 G28 V30 D51 V52 I53 T94 A95 R98 I119 V135 N137 H192 I251 G28 V30 D51 V52 I53 T94 A95 R98 I119 V135 N137 H192 I251 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 23628333 801 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4jnk D 1.896 BS02 ZHK D 1 Q99 R105 L108 N137 P138 D140 E191 H192 D194 Q99 R105 L108 N137 P138 D140 E191 H192 D194 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 Kd=5.1uM IC50=750nM, Kd=5100nM P00338 23628333 802 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF