4jlj A 2.0 BS01 1NM A 1 V55 Y86 F96 Q97 D133 F137 Y204 V36 Y58 F68 Q69 D105 F109 Y176 E53 R128 E34 R100 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=726.4nM -logKd/Ki=6.13, IC50=745.7nM IC50=230nM P27707 24419380 301 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNELTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4jlj A 2.0 BS02 1NM A 2 S59 L82 Y86 E197 G199 I200 P201 Y204 S40 L54 Y58 E169 G171 I172 P173 Y176 E53 R128 E34 R100 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=726.4nM -logKd/Ki=6.13, IC50=745.7nM IC50=230nM P27707 24419380 302 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNELTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4jlj A 2.0 BS03 UDP A 1 A31 G33 K34 S35 T36 R188 R192 D241 F242 K243 A12 G14 K15 S16 T17 R160 R164 D213 F214 K215 E53 R128 E34 R100 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 24419380 303 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNELTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4jlj B 2.0 BS01 1NM B 1 E53 P89 F96 Q97 D133 F137 S144 E35 P62 F69 Q70 D106 F110 S117 E53 R128 E35 R101 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=726.4nM IC50=230nM P27707 24419380 301 TRIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNELTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4jlj B 2.0 BS02 1NM B 2 S59 L82 Y86 E196 I200 P201 Y204 S41 L55 Y59 E169 I173 P174 Y177 E53 R128 E35 R101 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=726.4nM IC50=230nM P27707 24419380 302 TRIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNELTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4jlj B 2.0 BS03 UDP B 1 A31 G33 K34 S35 T36 R188 R192 D241 F242 K243 A13 G15 K16 S17 T18 R161 R165 D214 F215 K216 E53 R128 E35 R101 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 24419380 303 TRIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNELTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL