4jjf A 2.2 BS01 FE9 A 1 G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 C172 A206 V207 G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 C172 A206 V207 1.12.98.2 0006730,0015948,0016491,0019386,0047068 -logKd/Ki=8.00, Ki=10nM P32440 23873755 401 MKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPDIINKFIDDIKPGAIVTHACTIPTTKFYKIFEQKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEDAIETLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPASFAQMMAKESLEQITALMEKVGIDKMEENLDPGALLGTADSMNFGASAEILPTVFEILEKRKK 4jjf A 2.2 BS02 N2I A 1 C172 G205 A206 C252 C172 G205 A206 C252 1.12.98.2 0006730,0015948,0016491,0019386,0047068 Ki=10nM -logKd/Ki=8.00, Ki=10nM P32440 23873755 402 MKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPDIINKFIDDIKPGAIVTHACTIPTTKFYKIFEQKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEDAIETLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPASFAQMMAKESLEQITALMEKVGIDKMEENLDPGALLGTADSMNFGASAEILPTVFEILEKRKK 4jjf B 2.2 BS01 FE9 B 1 L6 G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 A171 C172 P204 A206 L6 G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 A171 C172 P204 A206 1.12.98.2 0006730,0015948,0016491,0019386,0047068 -logKd/Ki=8.00, Ki=10nM P32440 23873755 401 MKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPDIINKFIDDIKPGAIVTHACTIPTTKFYKIFEQKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEDAIETLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPASFAQMMAKESLEQITALMEKVGIDKMEENLDPGALLGTADSMNFGASAEILPTVFEILEKRKK 4jjf B 2.2 BS02 N2I B 1 C172 C252 C172 C252 1.12.98.2 0006730,0015948,0016491,0019386,0047068 Ki=10nM -logKd/Ki=8.00, Ki=10nM P32440 23873755 402 MKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPDIINKFIDDIKPGAIVTHACTIPTTKFYKIFEQKHGDLVTKPETLNVTSYHPGAVPEMKGQVYIAEGYASEDAIETLFELGQKARGNAYRLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPASFAQMMAKESLEQITALMEKVGIDKMEENLDPGALLGTADSMNFGASAEILPTVFEILEKRKK