4j24 A 2.1 BS01 peptide I 0 I310 K314 L324 V328 E332 D489 E493 I49 K53 L63 V67 E71 D216 E220 ? 0003677,0004879,0006355 Q92731 23437920 4 ~ 15 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 A 2.1 BS02 EST A 1 E305 F356 H475 L476 E44 F95 H202 L203 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 B 2.1 BS01 peptide J 0 I310 K314 L324 Q327 V328 E332 D489 L490 E493 I50 K54 L64 Q67 V68 E72 D219 L220 E223 ? 0003677,0004879,0006355 Q92731 23437920 4 ~ 14 DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 B 2.1 BS02 EST B 1 E305 L339 F356 I376 H475 L476 E45 L79 F96 I116 H205 L206 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 C 2.1 BS01 peptide K 0 I310 K314 L324 V328 E332 D489 E493 I49 K53 L63 V67 E71 D216 E220 ? 0003677,0004879,0006355 Q92731 23437920 4 ~ 15 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 C 2.1 BS02 EST C 1 L298 E305 F356 H475 L476 L37 E44 F95 H202 L203 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 ALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAH 4j24 D 2.1 BS01 peptide L 0 I310 K314 L324 V328 E332 D489 E493 M494 I47 K51 L61 V65 E69 D213 E217 M218 ? 0003677,0004879,0006355 Q92731 23437920 4 ~ 13 SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNA 4j24 D 2.1 BS02 EST D 1 E305 M336 F356 H475 L476 E42 M73 F93 H199 L200 ? 0003677,0004879,0006355 IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM Q92731 23437920 600 SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNA