4izy A 2.3 BS01 peptide B 0 R127 Y130 S161 D162 C163 W324 E329 R120 Y123 S154 D155 C156 W295 E300 D151 K153 N156 D169 T188 D144 K146 N149 D162 T166 2.7.11.24 0004672,0004707,0005524,0006468 P45983 23664880 154 ~ 162 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPREHTIEEWKELIYKEVM 4izy A 2.3 BS02 1J2 A 1 I32 S34 G35 Q37 G38 V40 A53 K55 M111 L168 I25 S27 G28 Q30 G31 V33 A46 K48 M104 L161 D151 K153 N156 D169 T188 D144 K146 N149 D162 T166 2.7.11.24 0004672,0004707,0005524,0006468 ic50=3nM -logKd/Ki=8.52, IC50=3nM IC50=3.1nM, Kd=0.140000nM P45983 23664880 401 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPREHTIEEWKELIYKEVM