4itj A 1.8 BS01 1HX A 1 M67 L70 V76 L78 M92 I154 A155 D156 S161 F162 M52 L55 V61 L63 M77 I139 A140 D141 S146 F147 D138 K140 E142 N143 D156 T189 D123 K125 E127 N128 D141 T156 2.7.11.1 0004672,0005524,0006468 ic50=0.3772uM -logKd/Ki=6.42, IC50=377.2nM Q13546 23473668 301 NVIKMKSSDFLEFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE 4itj B 1.8 BS01 1HX B 1 K45 M67 L70 V75 V76 L78 M92 I154 A155 D156 S161 K39 M61 L64 V69 V70 L72 M86 I148 A149 D150 S155 D138 K140 E142 N143 D156 T189 D132 K134 E136 N137 D150 T171 2.7.11.1 0004672,0005524,0006468 ic50=0.3772uM Q13546 23473668 301 LNVIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE