4ijp A 2.25 BS01 1EH A 1 T693 V701 A715 K717 L751 F767 L770 S771 M772 E776 L822 T24 V32 A46 K48 L82 F98 L101 S102 M103 E107 L153 D815 K817 N820 D834 S852 D146 K148 N151 D165 S183 2.7.11.1 0004672,0004674,0005524,0006468,0045292 ic50=0.016uM -logKd/Ki=7.80, IC50=0.016uM IC50=16nM Q13523 24003220 1101 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDEREKVTVMSTINPTKDLLADLIQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 4ijp B 2.25 BS01 1EH B 1 T693 V701 R703 K717 L751 L770 S771 M772 E776 L822 T26 V34 R36 K50 L84 L103 S104 M105 E109 L155 D815 K817 N820 D834 S852 D148 K150 N153 D167 S185 2.7.11.1 0004672,0004674,0005524,0006468,0045292 ic50=0.016uM IC50=16nM Q13523 24003220 1101 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE