4idv A 2.9 BS01 13V A 1 R408 V414 E440 I467 M469 E470 L472 G475 S476 Q479 L522 C533 D534 F535 R68 V74 E100 I127 M129 E130 L132 G135 S136 Q139 L182 C193 D194 F195 D515 K517 N520 D534 L551 T559 D175 K177 N180 D194 L211 T219 2.7.11.25 0004672,0004674,0005524,0006468 -logKd/Ki=7.40, IC50=0.04uM IC50=20nM Q99558 23374866 701 FSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHP 4idv B 2.9 BS01 13V B 1 R408 G409 V414 A427 K429 E440 M469 E470 L472 S476 Q479 L522 C533 D534 F535 R68 G69 V74 A87 K89 E100 M129 E130 L132 S136 Q139 L182 C193 D194 F195 D515 K517 N520 D534 L551 T559 D175 K177 N180 D194 L211 T219 2.7.11.25 0004672,0004674,0005524,0006468 IC50=20nM Q99558 23374866 701 FSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHP 4idv C 2.9 BS01 13V C 1 R408 V414 K429 E440 M469 E470 L471 L472 Q479 L522 C533 D534 F535 R68 V74 K89 E100 M129 E130 L131 L132 Q139 L182 C193 D194 F195 D515 K517 N520 D534 L551 T559 D175 K177 N180 D194 L211 T219 2.7.11.25 0004672,0004674,0005524,0006468 IC50=20nM Q99558 23374866 701 FSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHP 4idv D 2.9 BS01 13V D 1 R408 V414 K429 E440 M469 L471 L472 S476 Q479 L522 C533 D534 F535 R68 V74 K89 E100 M129 L131 L132 S136 Q139 L182 C193 D194 F195 D515 K517 N520 D534 L551 T559 D175 K177 N180 D194 L211 T219 2.7.11.25 0004672,0004674,0005524,0006468 IC50=20nM Q99558 23374866 701 FSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHP