4i9n A 2.35 BS01 1E6 A 1 G26 D51 V52 A95 G96 N114 I115 F118 G26 D51 V52 A95 G96 N107 I108 F111 D165 R168 H192 D158 R161 H185 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n A 2.35 BS02 1E5 A 1 G28 V30 T94 V135 S136 N137 R168 A237 T247 G28 V30 T94 V128 S129 N130 R161 A230 T240 D165 R168 H192 D158 R161 H185 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n B 2.35 BS01 1E6 B 1 G26 D51 V52 A95 G96 I115 F118 I119 G26 D51 V52 A95 G96 I108 F111 I112 L105 D165 R168 H192 L99 D158 R161 H185 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n B 2.35 BS02 1E5 B 1 V30 T94 V135 S136 N137 R168 A237 T247 V30 T94 V128 S129 N130 R161 A230 T240 L105 D165 R168 H192 L99 D158 R161 H185 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n C 2.35 BS01 1E6 C 1 G26 G28 D51 V52 A95 R111 I115 F118 I119 G26 G28 D51 V52 A95 R108 I112 F115 I116 R105 D165 R168 H192 R102 D162 R165 H189 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n C 2.35 BS02 1E5 C 1 G28 V30 T94 V135 S136 N137 R168 A237 T247 G28 V30 T94 V132 S133 N134 R165 A234 T244 R105 D165 R168 H192 R102 D162 R165 H189 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n D 2.35 BS01 1E6 D 1 G26 G28 D51 V52 A95 R111 N114 I115 F118 G26 G28 D51 V52 A95 R111 N114 I115 F118 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n D 2.35 BS02 1E5 D 1 V30 T94 V135 S136 N137 R168 A237 T247 V30 T94 V135 S136 N137 R168 A237 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n E 2.35 BS01 1E6 E 1 G26 G28 D51 V52 A95 G96 R111 N114 I115 F118 G26 G28 D51 V52 A95 G96 R111 N114 I115 F118 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n E 2.35 BS02 1E5 E 1 V30 T94 V135 S136 R168 A237 T247 V30 T94 V135 S136 R168 A237 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n F 2.35 BS01 1E6 F 1 G26 G28 D51 V52 A95 R111 N114 I115 F118 G24 G26 D49 V50 A93 R109 N112 I113 F116 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n F 2.35 BS02 1E5 F 1 V30 T94 V135 S136 N137 R168 A237 T247 V28 T92 V133 S134 N135 R166 A235 T245 R105 D165 R168 H192 R103 D163 R166 H190 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n G 2.35 BS01 1E6 G 1 G26 D51 V52 A95 G96 I115 F118 I119 G26 D51 V52 A95 G96 I112 F115 I116 R105 D165 R168 H192 R102 D162 R165 H189 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n G 2.35 BS02 1E5 G 1 V30 T94 V135 S136 N137 L164 R168 A237 T247 V30 T94 V132 S133 N134 L161 R165 A234 T244 R105 D165 R168 H192 R102 D162 R165 H189 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n H 2.35 BS01 1E6 H 1 G26 D51 V52 A95 G96 R111 I115 F118 I119 G26 D51 V52 A95 G96 R105 I109 F112 I113 R105 D165 R168 H192 R99 D159 R162 H186 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=360uM P13491 23302067 401 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGASRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF 4i9n H 2.35 BS02 1E5 H 1 G28 V30 T94 V135 S136 N137 R168 A237 T247 G28 V30 T94 V129 S130 N131 R162 A231 T241 R105 D165 R168 H192 R99 D159 R162 H186 1.1.1.27 0003824,0004459,0005737,0006089,0006090,0016491,0016616,0019752 Kd=1300uM P13491 23302067 402 AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGASRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSGMNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIGLSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDVVKVTLTSEEEAHLKKSADTLWGIQKELQF