4hnc A 1.889 BS01 MG A 1 D195 E221 E247 D193 E219 E245 V22 S139 K164 C166 D195 N197 E221 G246 E247 D270 M294 H297 L298 F299 A313 E317 V20 S137 K162 C164 D193 N195 E219 G244 E245 D268 M292 H295 L296 F297 A311 E315 5.1.2.2 0000287,0009063,0016052,0016836,0016853,0018838,0018924,0019596,0046872 P11444 24472022 401 EVLITGLRTRAVNVPLAYPVHTAVGTVGTAPLVLIDLATSAGVVGHSYLFAYTPVALKSLKQLLDDMAAMIVNEPLAPVSLEAMLAKRFSLAGYTGLIRMAAAGIDMAAWDALGKVHETPLVKLLGANARPVQAYDSHSLDGVKLATERAVTAAELGFRAVKTCIGYPALDQDLAVVRSIRQAVGDDFGIMVDYNQSLDVPAAIKRSQALQQEGVTWIEEPTLQHDYEGHQRIQSKLNVPVQMGENWLGPEEMFKALSIGASRLAMPDAMKIGGVTGWIRASALAQQFGIPMSSHLFQEISAHLLAATPTAHWLERLDLAGSVIEPTLTFEGGNAVIPDLPGVGIIWREKEIGKYLV 4hnc A 1.889 BS02 0UT A 1 K164 C166 D195 N197 E247 H297 E317 K162 C164 D193 N195 E245 H295 E315 V22 S139 K164 C166 D195 N197 E221 G246 E247 D270 M294 H297 L298 F299 A313 E317 V20 S137 K162 C164 D193 N195 E219 G244 E245 D268 M292 H295 L296 F297 A311 E315 5.1.2.2 0000287,0009063,0016052,0016836,0016853,0018838,0018924,0019596,0046872 Ki=0.67mM -logKd/Ki=3.17, Ki=0.67mM Ki=700000nM P11444 24472022 402 EVLITGLRTRAVNVPLAYPVHTAVGTVGTAPLVLIDLATSAGVVGHSYLFAYTPVALKSLKQLLDDMAAMIVNEPLAPVSLEAMLAKRFSLAGYTGLIRMAAAGIDMAAWDALGKVHETPLVKLLGANARPVQAYDSHSLDGVKLATERAVTAAELGFRAVKTCIGYPALDQDLAVVRSIRQAVGDDFGIMVDYNQSLDVPAAIKRSQALQQEGVTWIEEPTLQHDYEGHQRIQSKLNVPVQMGENWLGPEEMFKALSIGASRLAMPDAMKIGGVTGWIRASALAQQFGIPMSSHLFQEISAHLLAATPTAHWLERLDLAGSVIEPTLTFEGGNAVIPDLPGVGIIWREKEIGKYLV 4hnc B 1.889 BS01 MG B 1 D195 E221 E247 D187 E213 E239 V22 S139 K164 C166 D195 N197 E221 G246 E247 D270 M294 H297 L298 F299 A313 E317 V20 S131 K156 C158 D187 N189 E213 G238 E239 D262 M286 H289 L290 F291 A305 E309 5.1.2.2 0000287,0009063,0016052,0016836,0016853,0018838,0018924,0019596,0046872 P11444 24472022 401 EVLITGLRTRAVNVPLAYPVHGTAPLVLIDLATSAGVVGHSYLFAYTPVALKSLKQLLDDMAAMIVNEPLAPVSLEAMLAKRFSLAGYTGLIRMAAAGIDMAAWDALGKVHETPLVKLLGANARPVQAYDSHSLDGVKLATERAVTAAELGFRAVKTCIGYPALDQDLAVVRSIRQAVGDDFGIMVDYNQSLDVPAAIKRSQALQQEGVTWIEEPTLQHDYEGHQRIQSKLNVPVQMGENWLGPEEMFKALSIGASRLAMPDAMKIGGVTGWIRASALAQQFGIPMSSHLFQEISAHLLAATPTAHWLERLDLAGSVIEPTLTFEGGNAVIPDLPGVGIIWREKEIGKYLV 4hnc B 1.889 BS02 0UT B 1 K164 C166 D195 N197 E247 H297 E317 K156 C158 D187 N189 E239 H289 E309 V22 S139 K164 C166 D195 N197 E221 G246 E247 D270 M294 H297 L298 F299 A313 E317 V20 S131 K156 C158 D187 N189 E213 G238 E239 D262 M286 H289 L290 F291 A305 E309 5.1.2.2 0000287,0009063,0016052,0016836,0016853,0018838,0018924,0019596,0046872 Ki=0.67mM -logKd/Ki=3.17, Ki=0.67mM Ki=700000nM P11444 24472022 402 EVLITGLRTRAVNVPLAYPVHGTAPLVLIDLATSAGVVGHSYLFAYTPVALKSLKQLLDDMAAMIVNEPLAPVSLEAMLAKRFSLAGYTGLIRMAAAGIDMAAWDALGKVHETPLVKLLGANARPVQAYDSHSLDGVKLATERAVTAAELGFRAVKTCIGYPALDQDLAVVRSIRQAVGDDFGIMVDYNQSLDVPAAIKRSQALQQEGVTWIEEPTLQHDYEGHQRIQSKLNVPVQMGENWLGPEEMFKALSIGASRLAMPDAMKIGGVTGWIRASALAQQFGIPMSSHLFQEISAHLLAATPTAHWLERLDLAGSVIEPTLTFEGGNAVIPDLPGVGIIWREKEIGKYLV