4gkh A 1.863 BS01 KAN A 1 Q35 D165 D167 D198 N234 C235 D268 E269 F271 Q18 D148 D150 D181 N217 C218 D251 E252 F254 K55 D198 N203 D216 K38 D181 N186 D199 0005524,0016773,0046677 23758273 301 NLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh A 1.863 BS02 0J9 A 1 V33 F53 I101 I215 V16 F36 I84 I198 K55 D198 N203 D216 K38 D181 N186 D199 0005524,0016773,0046677 -logKd/Ki=4.67, Ki=21.5uM 23758273 302 NLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh B 1.863 BS01 KAN A 1 S2 H3 S2 H3 K55 D198 N203 D216 K52 D195 N200 D213 0005524,0016773,0046677 23758273 301 MSHIQRETSCSRPRLNSNLDADLYGYRWARDQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh B 1.863 BS02 KAN B 1 D165 D167 D198 N234 C235 E238 D268 E269 F271 D162 D164 D195 N231 C232 E235 D265 E266 F268 K55 D198 N203 D216 K52 D195 N200 D213 0005524,0016773,0046677 23758273 301 MSHIQRETSCSRPRLNSNLDADLYGYRWARDQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh B 1.863 BS03 0J9 B 1 F53 I101 I215 F50 I98 I212 K55 D198 N203 D216 K52 D195 N200 D213 0005524,0016773,0046677 23758273 302 MSHIQRETSCSRPRLNSNLDADLYGYRWARDQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh C 1.863 BS01 KAN C 1 Q35 D165 D167 D198 R219 N234 E238 D268 E269 F271 Q31 D161 D163 D194 R215 N230 E234 D264 E265 F267 K55 D198 N203 D216 K51 D194 N199 D212 0005524,0016773,0046677 23758273 301 QRETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh C 1.863 BS02 0J9 C 1 D31 F53 I101 I215 D27 F49 I97 I211 K55 D198 N203 D216 K51 D194 N199 D212 0005524,0016773,0046677 23758273 302 QRETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh D 1.863 BS01 0J9 C 2 F53 I101 I215 F47 I95 I209 K55 D198 N203 D216 K49 D192 N197 D210 0005524,0016773,0046677 23758273 303 HIQRETSCSRPRLNSNLDADLYGYRWARDNGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh D 1.863 BS02 KAN D 1 D165 D167 D198 N234 C235 D268 E269 F271 D159 D161 D192 N228 C229 D262 E263 F265 K55 D198 N203 D216 K49 D192 N197 D210 0005524,0016773,0046677 23758273 301 HIQRETSCSRPRLNSNLDADLYGYRWARDNGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh E 1.863 BS01 KAN E 1 Q35 D165 D167 D198 N234 D268 E269 F271 Q25 D155 D157 D188 N224 D258 E259 F261 K55 D198 N203 D216 K45 D188 N193 D206 0005524,0016773,0046677 23758273 301 SRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh E 1.863 BS02 0J9 E 1 F53 I101 I215 F43 I91 I205 K55 D198 N203 D216 K45 D188 N193 D206 0005524,0016773,0046677 23758273 302 SRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh F 1.863 BS01 KAN E 1 S2 H3 S2 H3 K55 D198 N203 D216 K55 D198 N203 D216 0005524,0016773,0046677 23758273 301 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh F 1.863 BS02 KAN F 1 D165 D167 D198 N234 E238 D268 E269 F271 D165 D167 D198 N234 E238 D268 E269 F271 K55 D198 N203 D216 K55 D198 N203 D216 0005524,0016773,0046677 23758273 301 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh F 1.863 BS03 0J9 F 1 F53 I101 I215 F53 I101 I215 K55 D198 N203 D216 K55 D198 N203 D216 0005524,0016773,0046677 23758273 302 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh G 1.863 BS01 KAN G 1 D165 D167 D198 N234 E238 D268 E269 F271 D161 D163 D194 N230 E234 D264 E265 F267 K55 D198 N203 D216 K51 D194 N199 D212 0005524,0016773,0046677 23758273 301 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh G 1.863 BS02 0J9 G 1 F53 I101 I215 F49 I97 I211 K55 D198 N203 D216 K51 D194 N199 D212 0005524,0016773,0046677 23758273 302 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh H 1.863 BS01 KAN H 1 D165 D167 D198 N234 C235 E238 D268 E269 F271 D149 D151 D182 N218 C219 E222 D252 E253 F255 K55 D198 N203 D216 K39 D182 N187 D200 0005524,0016773,0046677 23758273 301 SNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh H 1.863 BS02 0J9 H 1 F53 I101 I215 D216 F37 I85 I199 D200 K55 D198 N203 D216 K39 D182 N187 D200 0005524,0016773,0046677 23758273 302 SNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh I 1.863 BS01 KAN I 1 Q35 D165 D167 D198 R219 E238 D268 E269 F271 Q30 D160 D162 D193 R214 E233 D263 E264 F266 K55 D198 N203 D216 K50 D193 N198 D211 0005524,0016773,0046677 23758273 301 RETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh I 1.863 BS02 0J9 I 1 F53 I101 I215 D216 F48 I96 I210 D211 K55 D198 N203 D216 K50 D193 N198 D211 0005524,0016773,0046677 23758273 302 RETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh J 1.863 BS01 KAN J 1 D165 D167 D198 D268 E269 F271 D161 D163 D194 D264 E265 F267 K55 D198 N203 D216 K51 D194 N199 D212 0005524,0016773,0046677 23758273 301 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh J 1.863 BS02 0J9 J 1 F53 I101 I215 F49 I97 I211 K55 D198 N203 D216 K51 D194 N199 D212 0005524,0016773,0046677 23758273 302 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh K 1.863 BS01 KAN K 1 D165 D167 D198 N234 E238 D268 E269 F271 D163 D165 D196 N232 E236 D266 E267 F269 K55 D198 N203 D216 K53 D196 N201 D214 0005524,0016773,0046677 23758273 301 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNVSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh K 1.863 BS02 0J9 K 1 D31 F53 A100 I101 I215 D31 F51 A98 I99 I213 K55 D198 N203 D216 K53 D196 N201 D214 0005524,0016773,0046677 23758273 302 MSHIQRETSCSRPRLNSNLDADLYGYRWARDNVSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh L 1.863 BS01 KAN L 1 D165 D167 D198 N234 C235 E238 D268 E269 F271 D148 D150 D181 N217 C218 E221 D251 E252 F254 K55 D198 N203 D216 K38 D181 N186 D199 0005524,0016773,0046677 23758273 301 NLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF 4gkh L 1.863 BS02 0J9 L 1 D31 F53 A100 I101 I215 D216 D14 F36 A83 I84 I198 D199 K55 D198 N203 D216 K38 D181 N186 D199 0005524,0016773,0046677 23758273 302 NLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF