4g2r A 2.28 BS01 H1L A 1 G98 A99 F115 G137 G138 Y141 G86 A87 F103 G125 G126 Y129 A99 G137 G138 Y326 G366 A367 A87 G125 G126 Y300 G340 A341 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 501 LDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG 4g2r A 2.28 BS02 H1L A 2 A140 V157 H184 H185 S188 V190 A128 V145 H159 H160 S163 V165 A99 G137 G138 Y326 G366 A367 A87 G125 G126 Y300 G340 A341 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 502 LDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG 4g2r A 2.28 BS03 H1L B 1 L295 Y326 V337 G366 L270 Y300 V311 G340 A99 G137 G138 Y326 G366 A367 A87 G125 G126 Y300 G340 A341 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 501 LDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG 4g2r A 2.28 BS04 H1L B 2 E333 W334 V338 E307 W308 V312 A99 G137 G138 Y326 G366 A367 A87 G125 G126 Y300 G340 A341 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 502 LDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG 4g2r B 2.28 BS01 H1L A 1 L295 Y326 G366 L270 Y301 G341 A99 G137 G138 Y326 G366 A367 A86 G124 G125 Y301 G341 A342 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 501 DPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG 4g2r B 2.28 BS02 H1L A 2 E333 W334 G335 V338 E308 W309 G310 V313 A99 G137 G138 Y326 G366 A367 A86 G124 G125 Y301 G341 A342 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 502 DPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG 4g2r B 2.28 BS03 H1L B 1 A99 F115 G137 G138 Y141 A86 F102 G124 G125 Y128 A99 G137 G138 Y326 G366 A367 A86 G124 G125 Y301 G341 A342 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 501 DPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG 4g2r B 2.28 BS04 H1L B 2 A140 V159 H184 H185 S188 V190 A127 V146 H159 H160 S163 V165 A99 G137 G138 Y326 G366 A367 A86 G124 G125 Y301 G341 A342 2.1.3.-,2.1.3.15 0003989,0004658,0005515,0006633,0009274,0009317,0016740,0016874,0019367 Kd=35.8uM -logKd/Ki=4.45, Kd=35.8uM P9WQH5 25092705 502 DPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRG