4fk6 A 2.2 BS01 0UJ A 1 R879 L881 V889 A906 F958 L959 E966 R1007 N1008 L1010 R17 L19 V25 A42 F91 L92 E99 R140 N141 L143 D1003 A1005 R1007 N1008 D1021 D1040 D136 A138 R140 N141 D154 D173 2.7.10.2 0004672,0004713,0005524,0006468 Ki=0.2nM -logKd/Ki=9.70, Ki=0.2nM Ki=3.2nM, EC50=355nM, IC50=1.000nM P23458 23107482 1201 TEVDPTHFEKRFLKRIRDLGEFGKVELCRYDPEGDNTGEQVAVKSLKPENHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 4fk6 B 2.2 BS01 0UJ B 1 L881 V889 A906 F958 L959 E966 R1007 N1008 L1010 G1020 L18 V26 A43 F90 L91 E98 R139 N140 L142 G152 D1003 A1005 R1007 N1008 D1021 D1040 D135 A137 R139 N140 D153 D172 2.7.10.2 0004672,0004713,0005524,0006468 Ki=0.2nM Ki=3.2nM, EC50=355nM, IC50=1.000nM P23458 23107482 1201 EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPENHIADLKKEIEILRNLYHENIVKYKGICTEGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK