4eb8 A 2.3 BS01 PO4 A 1 G32 S33 R84 H86 N115 S220 G34 S35 R86 H88 N117 S222 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 A 2.3 BS02 IM5 A 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 W257 V260 Y90 A118 A119 G120 F202 E203 V219 M221 N245 W259 V262 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=9.82, Ki=151pM Ki=7nM P00491 23438750 302 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 B 2.3 BS01 PO4 B 1 G32 S33 H64 R84 H86 N115 S220 G34 S35 H66 R86 H88 N117 S222 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 B 2.3 BS02 IM5 B 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 Y90 A118 A119 G120 F202 E203 V219 M221 N245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S35 H66 H88 Y90 E91 A118 M221 S222 N245 V247 W259 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 Ki=7nM P00491 23438750 302 TLMENGYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 C 2.3 BS01 PO4 C 1 G32 S33 R84 H86 N115 S220 G29 S30 R81 H83 N112 S217 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 23438750 301 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD 4eb8 C 2.3 BS02 IM5 C 1 Y88 A116 A117 G118 F200 E201 V217 M219 N243 W257 Y85 A113 A114 G115 F197 E198 V214 M216 N240 W254 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 W257 S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 W254 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 -logKd/Ki=9.82, Ki=151pM Ki=7nM P00491 23438750 302 GYTYEDYKNTAEYLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLYKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTYKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAAGKQAAQKLEQFVSILMASIPLPD