4e4x A 3.6 BS01 T1Q A 1 A481 K483 L505 L514 T529 C532 F583 D594 F595 G596 A34 K36 L58 L67 T82 C85 F136 D147 F148 G149 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S162 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.15, IC50=7nM IC50=41nM P15056 22534450 801 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 4e4x B 3.6 BS01 T1Q B 1 V471 A481 K483 L514 T529 C532 S536 F583 D594 F595 G596 V24 A34 K36 L67 T82 C85 S89 F136 D147 F148 G149 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S169 2.7.11.1 0004672,0005524,0006468 IC50=41nM P15056 22534450 801 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL