4e4l A 2.0 BS01 0NH A 1 G882 E883 V889 A906 M956 F958 L959 R1007 N1008 L1010 D1021 G18 E19 V25 A42 M81 F83 L84 R132 N133 L135 D146 D1003 A1005 R1007 N1008 D1021 D1040 D128 A130 R132 N133 D146 D165 2.7.10.2 0004672,0004713,0005524,0006468 Ki=1.7nM -logKd/Ki=8.77, Ki=1.7nM EC50=210nM, Ki=1.7nM P23458 22591402 1201 VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKHIADLKKEIEILRNLYHENIVKYKGICTGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 4e4l B 2.0 BS01 0NH B 1 L881 G882 E883 V889 A906 M956 E957 F958 L959 R1007 N1008 L1010 G1020 D1021 L18 G19 E20 V26 A43 M83 E84 F85 L86 R134 N135 L137 G147 D148 D1003 A1005 R1007 N1008 D1021 D1040 D130 A132 R134 N135 D148 D167 2.7.10.2 0004672,0004713,0005524,0006468 Ki=1.7nM EC50=210nM, Ki=1.7nM P23458 22591402 1201 EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKNHIADLKKEIEILRNLYHENIVKYKGICTGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 4e4l D 2.0 BS01 0NH D 1 E883 V889 A906 M956 E957 F958 L959 R1007 L1010 G1020 D1021 E20 V26 A43 M85 E86 F87 L88 R136 L139 G149 D150 D1003 A1005 R1007 N1008 D1021 D1040 D132 A134 R136 N137 D150 D169 2.7.10.2 0004672,0004713,0005524,0006468 Ki=1.7nM EC50=210nM, Ki=1.7nM P23458 22591402 1201 EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKHIADLKKEIEILRNLYHENIVKYKGICTGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 4e4l E 2.0 BS01 0NH A 2 L881 G882 E883 V889 A906 M956 F958 L959 R1007 N1008 L1010 D1021 L18 G19 E20 V26 A43 M84 F86 L87 R135 N136 L138 D149 N1008 D1021 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 EC50=210nM, Ki=1.7nM P23458 22591402 1202 EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPNHIADLKKEIEILRNLYHENIVKYKGICTGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK