4dwv A 1.14 BS01 ZN A 1 C46 H67 C174 C46 H67 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 22531044 375 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 4dwv A 1.14 BS02 ZN A 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 22531044 376 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 4dwv A 1.14 BS03 NAJ A 1 C46 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 C46 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 I269 V292 G293 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 22531044 377 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 4dwv A 1.14 BS04 PFB A 1 S48 L57 H67 F93 L116 L141 C174 V294 I318 S48 L57 H67 F93 L116 L141 C174 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.52uM P00327 22531044 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 4dwv B 1.14 BS01 ZN B 1 C46 H67 C174 C46 H67 C174 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 22531044 375 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 4dwv B 1.14 BS02 ZN B 2 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 22531044 376 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 4dwv B 1.14 BS03 NAJ B 1 C46 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 K228 V268 I269 V292 G293 V294 I318 C46 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 K228 V268 I269 V292 G293 V294 I318 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 P00327 22531044 377 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF 4dwv B 1.14 BS04 PFB B 1 S48 L57 H67 F93 L116 L141 C174 V294 S48 L57 H67 F93 L116 L141 C174 V294 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.1 0004022,0004745,0005737,0005829,0008270,0016491,0042572,0042573,0046872 Ki=0.52uM P00327 22531044 378 STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGESIRTILTF