4dwg A 2.01 BS01 MG A 1 D98 D102 D98 D102 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q95WL3 22715997 402 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRK 4dwg A 2.01 BS02 MG A 2 D98 D102 D98 D102 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q95WL3 22715997 403 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRK 4dwg A 2.01 BS03 0M8 A 1 Y94 D98 R107 Q167 K207 D250 K264 Y94 D98 R107 Q167 K207 D250 K264 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 K48 H93 D98 D102 R107 D170 K207 F246 D250 D251 2.5.1.10 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50=58nM -logKd/Ki=7.24, IC50=58.0nM Q95WL3 22715997 404 MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRK