4do1 A 2.0 BS01 HEM A 1 I97 L98 H105 R109 A248 G249 T252 F298 R300 G350 F351 H356 C358 V359 G360 A364 I81 L82 H89 R93 A232 G233 T236 F282 R284 G334 F335 H340 C342 V343 G344 A348 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 501 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 A 2.0 BS02 ANN A 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=0.28uM Q2IU02 22695988 502 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 A 2.0 BS03 CL A 1 Y177 Q203 Y161 Q187 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 505 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 B 2.0 BS01 HEM B 1 I97 L98 H105 R109 A248 G249 T252 F298 R300 G350 F351 H356 C358 V359 G360 A364 I81 L82 H89 R93 A232 G233 T236 F282 R284 G334 F335 H340 C342 V343 G344 A348 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 501 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 B 2.0 BS02 ANN B 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=0.28uM Q2IU02 22695988 502 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 B 2.0 BS03 CL B 1 Y177 Q203 Y161 Q187 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 506 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 C 2.0 BS01 HEM C 1 I97 L98 H105 R109 A248 G249 T252 V295 F298 R300 G350 F351 H356 C358 V359 G360 A364 I81 L82 H89 R93 A232 G233 T236 V279 F282 R284 G334 F335 H340 C342 V343 G344 A348 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 501 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 C 2.0 BS02 ANN C 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=0.28uM Q2IU02 22695988 502 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 C 2.0 BS03 CL C 1 Y177 Q203 Y161 Q187 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 505 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 D 2.0 BS01 HEM D 1 I97 L98 H105 R109 A248 G249 T252 F298 R300 G350 F351 H356 C358 V359 G360 A364 I81 L82 H89 R93 A232 G233 T236 F282 R284 G334 F335 H340 C342 V343 G344 A348 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 501 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 D 2.0 BS02 ANN D 1 S95 L98 F182 S244 S247 A248 F298 S79 L82 F166 S228 S231 A232 F282 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Kd=0.28uM Q2IU02 22695988 502 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA 4do1 D 2.0 BS03 CL D 1 Y177 Q203 Y161 Q187 N183 A248 D251 T252 T253 C358 V359 G360 E367 L396 N167 A232 D235 T236 T237 C342 V343 G344 E351 L380 ? 0004497,0005506,0016705,0020037,0046872 Q2IU02 22695988 505 TIPHLAIDPFSLDFFDDPYPDQQTLRDAGPVVYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLPVKLTPA