4ddy A 1.36 BS01 DN6 A 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 D240 N76 Y77 S102 N104 P139 N142 T143 T207 G208 S209 D211 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM -logKd/Ki=5.62, Ki=2.4uM Q9L5C8 22296601 301 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy A 1.36 BS02 DN6 A 2 N104 Y105 T216 S237 N76 Y77 T188 S209 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM -logKd/Ki=5.62, Ki=2.4uM Q9L5C8 22296601 302 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy A 1.36 BS03 DN6 A 3 T51 N54 R191 Q192 G196 T24 N27 R163 Q164 G168 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM -logKd/Ki=5.62, Ki=2.4uM Q9L5C8 22296601 303 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy B 1.36 BS01 DN6 B 1 K111 H112 A124 A125 Y129 K84 H85 A97 A98 Y102 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM Q9L5C8 22296601 301 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy B 1.36 BS02 DN6 B 2 N104 Y105 T216 N77 Y78 T189 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM Q9L5C8 22296601 302 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy B 1.36 BS03 DN6 B 3 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 D240 N77 Y78 S103 N105 P140 N143 T144 T208 G209 S210 D212 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM Q9L5C8 22296601 303 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy B 1.36 BS04 DN6 B 4 N92 Q93 P94 N65 Q66 P67 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM Q9L5C8 22296601 304 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy B 1.36 BS05 DN6 B 5 Q87 K88 Q89 L90 Q60 K61 Q62 L63 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM Q9L5C8 22296601 306 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy B 1.36 BS06 DN6 B 6 Q30 Q56 L59 Y60 R61 G62 Q4 Q30 L32 Y33 R34 G35 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM Q9L5C8 22296601 307 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ddy B 1.36 BS07 DN6 B 7 Q254 R256 L290 Q225 R227 L261 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=2.4uM Q9L5C8 22296601 308 SAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL