4d2w A 1.92 BS01 NF5 A 1 I17 A38 C89 P90 L139 I17 A38 C86 P87 L136 D132 K134 E136 N137 D150 A171 D129 K131 E133 N134 D147 A155 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=4.51, IC50=31uM IC50=31000nM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCACGALAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2w B 1.92 BS01 NF5 B 1 I17 A38 Y88 C89 P90 I17 A38 Y88 C89 P90 D132 K134 E136 N137 D150 A171 D132 K134 E136 N137 D150 A165 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 IC50=31000nM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDCGALAYAAPELIQGGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2w B 1.92 BS02 NF5 C 1 T16 I17 T16 I17 D132 K134 E136 N137 D150 A171 D132 K134 E136 N137 D150 A165 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 IC50=31000nM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDCGALAYAAPELIQGGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2w C 1.92 BS01 NF5 C 1 A38 E87 C89 P90 L139 A38 E83 C85 P86 L135 D132 K134 E136 N137 D150 A171 D128 K130 E132 N133 D146 A154 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 IC50=31000nM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKGALAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2w D 1.92 BS01 NF5 A 1 T16 I17 T16 I17 D132 K134 E136 N137 D150 A171 D132 K134 E136 N137 D150 A164 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=4.51, IC50=31uM IC50=31000nM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKCGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2w D 1.92 BS02 NF5 D 1 L27 A38 Y88 C89 P90 L139 L27 A38 Y88 C89 P90 L139 D132 K134 E136 N137 D150 A171 D132 K134 E136 N137 D150 A164 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=4.51, IC50=31uM IC50=31000nM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKCGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR