4d2p A 2.55 BS01 6Z7 A 1 L27 A38 K40 E57 L61 C70 L86 C89 P90 L139 I149 D150 L27 A38 K40 E54 L58 C67 L83 C86 P87 L136 I146 D147 D132 K134 E136 N137 D150 A171 D129 K131 E133 N134 D147 A154 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAGALAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2p B 2.55 BS01 6Z7 B 1 L27 A38 K40 E57 L61 C70 Y88 C89 P90 L139 I149 D150 L27 A38 K40 E57 L61 C70 Y88 C89 P90 L139 I149 D150 D132 K134 E136 N137 D150 A171 D132 K134 E136 N137 D150 A165 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=5.68, IC50=2.1uM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDCGALAYAAPELIQGGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2p C 2.55 BS01 6Z7 C 1 L27 A38 K40 E57 L61 C70 Y88 C89 P90 L139 I149 D150 L28 A39 K41 E55 L59 C68 Y86 C87 P88 L137 I147 D148 D132 K134 E136 N137 D150 A171 D130 K132 E134 N135 D148 A156 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=5.68, IC50=2.1uM Q14680 25589925 1334 HMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKGALAYAAPELIQGKSGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2p D 2.55 BS01 6Z7 D 1 L27 K40 E57 L61 C70 L86 Y88 C89 P90 L139 I149 D150 L27 K40 E57 L61 C70 L86 Y88 C89 P90 L139 I149 D150 D132 K134 E136 N137 D150 A171 D132 K134 E136 N137 D150 A164 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKFIHLDDVTELSVHHRNNRQISLWQYDHLTATYLLLLAKKARGKPVRLR