4d1j A 1.8 BS01 DGJ A 1 N67 K134 N135 N204 E205 E349 F374 N383 N31 K98 N99 N168 E169 E313 F338 N347 3.2.1.23 0004565,0005975,0009341 Kd=485nM -logKd/Ki=6.31, Kd=485nM B3PBE0 25171165 600 APLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ 4d1j B 1.8 BS01 DGJ B 1 N67 K134 N135 N204 E205 E349 F374 N383 N31 K98 N99 N168 E169 E313 F338 N347 3.2.1.23 0004565,0005975,0009341 Kd=485nM B3PBE0 25171165 600 APLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ 4d1j C 1.8 BS01 DGJ C 1 K134 N135 N204 E205 E349 F374 N383 K98 N99 N168 E169 E313 F338 N347 3.2.1.23 0004565,0005975,0009341 Kd=485nM B3PBE0 25171165 600 APLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ 4d1j D 1.8 BS01 DGJ D 1 N67 K134 N135 N204 E205 E349 F374 N383 N32 K99 N100 N169 E170 E314 F339 N348 3.2.1.23 0004565,0005975,0009341 Kd=485nM B3PBE0 25171165 600 AAPLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ 4d1j E 1.8 BS01 DGJ E 1 N67 K134 N135 N204 E205 E349 F374 N383 N31 K98 N99 N168 E169 E313 F338 N347 3.2.1.23 0004565,0005975,0009341 Kd=485nM B3PBE0 25171165 600 APLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ 4d1j F 1.8 BS01 DGJ F 1 N67 K134 N135 N204 E205 E349 F374 N383 N31 K98 N99 N168 E169 E313 F338 N347 3.2.1.23 0004565,0005975,0009341 Kd=485nM B3PBE0 25171165 600 APLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ 4d1j G 1.8 BS01 DGJ G 1 N67 K134 N135 N204 E205 E349 F374 N383 N32 K99 N100 N169 E170 E314 F339 N348 3.2.1.23 0004565,0005975,0009341 Kd=485nM B3PBE0 25171165 600 AAPLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ 4d1j H 1.8 BS01 DGJ H 1 K134 N135 N204 E205 E349 F374 N383 K98 N99 N168 E169 E313 F338 N347 3.2.1.23 0004565,0005975,0009341 Kd=485nM B3PBE0 25171165 600 APLPELLSNNGKHALMVDGAPYIILGSQTNNSSNYPDALKDVWPSMEKMGANTLSIPVAWEQIEPVEGQFDFSFVDVLLKEARQRKVRLVLLWFATWKNNAPHYAPAWVKLDNARFPRVVKEDGDTLNSLSPLGQNTLAADKKAFVELMKYLAKRDKDHTVIMVQVQNEVGTYGAVRDYSPMAQAVFNAAVPDDLIQKLQLKPGTWSQVFGRDADEFFHAYQIARYCDEVTVAGKAIKNLPMYVNVALRNPFNPGLPGQYSSGGGTDNVLHIWKAAAPNIDLIAPDIYFRDYKTVSKVLELYTRPDNALFVAEIGNDQPFARYLFPTLGKGGIGFSPFGMDDTDYTNYPLGAKVYNDETIEQFAQVYRLVNPMMREWARLSYQGQVWGVAEPLDSTTETQKIWNAEATPEEKEQHKKDRASALTQQLDLGLWDAEVTYGRPMFWVTPPEGNTPAAGGALIAQLDDNEYLVTAYKARVEFKPSQELAGKKFMIERVEEGRFEKGKWVMERVWNGDQTDWGLNFTDRPHLLRVKMASYSVQ