4cqm A 2.339 BS01 NAP A 1 G18 S21 G22 I23 D42 L43 A74 V76 C103 A104 G105 I106 V126 I154 S156 Y169 K173 P199 G200 I202 T204 P205 M206 T207 G13 S16 G17 I18 D37 L38 A61 V63 C90 A91 G92 I93 V113 I141 S143 Y156 K160 P186 G187 I189 T191 P192 M193 T194 G22 S156 Y169 K173 G17 S143 Y156 K160 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 QNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM 4cqm B 2.339 BS01 NAP B 1 G9 R12 I14 A33 R34 D56 V57 A83 A84 G85 G134 Y148 P178 G13 R16 I18 A37 R38 D60 V61 A87 A88 G89 G138 Y152 P182 G13 S135 Q145 Y148 K152 G17 S139 Q149 Y152 K156 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 HHHHMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm C 2.339 BS01 NAP C 1 G9 S11 R12 G13 I14 A33 R34 N35 D56 V57 A84 G85 I86 T106 G7 S9 R10 G11 I12 A31 R32 N33 D54 V55 A82 G83 I84 T104 G13 S135 Q145 Y148 K152 G11 S133 Q143 Y146 K150 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm D 2.339 BS01 NAP D 1 G18 S21 G22 I23 D42 L43 A74 D75 V76 C103 A104 G105 I106 V126 I154 S155 S156 Y169 K173 P199 G200 I202 T204 M206 T207 G16 S19 G20 I21 D40 L41 A61 D62 V63 C90 A91 G92 I93 V113 I141 S142 S143 Y156 K160 P186 G187 I189 T191 M193 T194 G22 S156 Y169 K173 G20 S143 Y156 K160 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 SQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM 4cqm E 2.339 BS01 NAP E 1 G18 S21 G22 I23 D42 L43 D75 V76 C103 A104 G105 I106 V126 I154 S156 Y169 K173 P199 G200 I202 T204 P205 M206 G16 S19 G20 I21 D40 L41 D62 V63 C90 A91 G92 I93 V113 I141 S143 Y156 K160 P186 G187 I189 T191 P192 M193 G22 S156 Y169 K173 G20 S143 Y156 K160 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 SQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM 4cqm F 2.339 BS01 NAP F 1 G9 R12 G13 I14 A33 R34 N35 D56 V57 A83 A84 G85 V133 S135 Y148 K152 V181 T183 M185 G13 R16 G17 I18 A37 R38 N39 D60 V61 A87 A88 G89 V137 S139 Y152 K156 V185 T187 M189 G13 S135 Q145 Y148 K152 G17 S139 Q149 Y152 K156 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 HHHHMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm G 2.339 BS01 NAP G 1 G9 S11 R12 A33 R34 N35 D56 A84 T106 G5 S7 R8 A29 R30 N31 D49 A77 T99 G13 S135 Q145 Y148 K152 G9 S128 Q138 Y141 K145 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 CAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm H 2.339 BS01 NAP H 1 G18 S21 G22 I23 D42 L43 A74 D75 V76 C103 G105 I154 S155 S156 Y169 K173 P199 G200 I202 T204 P205 M206 G17 S20 G21 I22 D41 L42 A62 D63 V64 C91 G93 I142 S143 S144 Y157 K161 P187 G188 I190 T192 P193 M194 G22 S156 Y169 K173 G21 S144 Y157 K161 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 ASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM 4cqm I 2.339 BS01 NAP I 1 G18 S21 G22 I23 D42 L43 A74 D75 V76 C103 A104 G105 I106 V126 I154 S156 Y169 K173 P199 G200 T204 P205 M206 G15 S18 G19 I20 D39 L40 A62 D63 V64 C91 A92 G93 I94 V114 I142 S144 Y157 K161 P187 G188 T192 P193 M194 G22 S156 Y169 K173 G19 S144 Y157 K161 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 QLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM 4cqm J 2.339 BS01 NAP J 1 G9 S11 R12 I14 A33 R34 D56 V57 A83 A84 G85 I86 V133 S135 Y148 K152 P178 V181 T183 M185 G12 S14 R15 I17 A36 R37 D59 V60 A86 A87 G88 I89 V136 S138 Y151 K155 P181 V184 T186 M188 G13 S135 Q145 Y148 K152 G16 S138 Q148 Y151 K155 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 HHHMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm K 2.339 BS01 NAP K 1 G9 S11 R12 G13 I14 A33 R34 N35 C55 D56 V57 A84 G85 T106 V133 Y148 K152 G9 S11 R12 G13 I14 A33 R34 N35 C55 D56 V57 A84 G85 T106 V133 Y148 K152 G13 S135 Q145 Y148 K152 G13 S135 Q145 Y148 K152 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm L 2.339 BS01 NAP L 1 G18 S21 G22 I23 D42 L43 A74 D75 V76 C103 A104 G105 I106 V126 S156 Y169 K173 P199 G200 T204 M206 T207 G15 S18 G19 I20 D39 L40 A59 D60 V61 C88 A89 G90 I91 V111 S141 Y154 K158 P184 G185 T189 M191 T192 G22 S156 Y169 K173 G19 S141 Y154 K158 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 QLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM 4cqm M 2.339 BS01 NAP M 1 G18 S21 G22 I23 D42 L43 A74 D75 V76 C103 A104 G105 I106 V126 I154 S156 Y169 K173 P199 G200 I202 T204 P205 M206 T207 G16 S19 G20 I21 D40 L41 A62 D63 V64 C91 A92 G93 I94 V114 I142 S144 Y157 K161 P187 G188 I190 T192 P193 M194 T195 G22 S156 Y169 K173 G20 S144 Y157 K161 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 SQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM 4cqm N 2.339 BS01 NAP N 1 G9 S11 R12 I14 A33 R34 C55 D56 V57 A83 A84 G85 V133 S135 Y148 K152 G12 S14 R15 I17 A36 R37 C58 D59 V60 A86 A87 G88 V136 S138 Y151 K155 G13 S135 Q145 Y148 K152 G16 S138 Q148 Y151 K155 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 HHHMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm O 2.339 BS01 NAP O 1 R12 I14 A33 R34 D56 V57 A83 A84 I86 T106 S135 Y148 V181 R12 I14 A33 R34 D56 V57 A83 A84 I86 T106 S135 Y148 V181 G13 S135 Q145 Y148 K152 G13 S135 Q145 Y148 K152 1.1.1.100,1.6.5.10 0003955,0004316,0005515,0005739,0005759,0006633,0008753,0016491,0016616,0044597,0044598,0046949,0048038,0051289,0051290,0055114,0070402,1990204 Kd=26.8uM Q8N4T8 25203508 301 MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL 4cqm P 2.339 BS01 NAP P 1 G18 S21 I23 D42 L43 A74 D75 V76 C103 G105 I106 V126 S155 S156 Y169 K173 P199 G200 T204 P205 M206 G16 S19 I21 D40 L41 A61 D62 V63 C90 G92 I93 V113 S142 S143 Y156 K160 P186 G187 T191 P192 M193 G22 S156 Y169 K173 G20 S143 Y156 K160 1.1.1.239,1.1.1.62,1.1.1.n12 0004303,0005515,0005739,0005740,0005759,0005886,0006633,0006694,0006703,0008209,0008210,0016020,0016491,0047035,0051290,0070404,0106386,1990204 Kd=26.8uM Q92506 25203508 301 SQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM