4cpz A 2.2 BS01 CA A 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz A 2.2 BS02 ZMR A 1 R115 E116 D148 R149 W176 E225 E274 E275 R291 N293 R373 Y408 R40 E41 D73 R74 W101 E150 E199 E200 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM -logKd/Ki=7.68, Ki=20.85nM U5XBU0 24795482 1471 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz B 2.2 BS01 CA B 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz B 2.2 BS02 ZMR B 1 R115 E116 D148 R149 W176 E225 A244 E274 R291 R373 Y408 R40 E41 D73 R74 W101 E150 A169 E199 R216 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM U5XBU0 24795482 1471 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz C 2.2 BS01 CA C 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz C 2.2 BS02 ZMR C 1 R115 E116 D148 R149 W176 R222 E225 A244 E274 R291 N293 R373 Y408 R40 E41 D73 R74 W101 R147 E150 A169 E199 R216 N218 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM U5XBU0 24795482 1470 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz D 2.2 BS01 CA D 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz D 2.2 BS02 ZMR D 1 R115 E116 D148 W176 R222 E225 E274 E275 R291 R373 Y408 R40 E41 D73 W101 R147 E150 E199 E200 R216 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM U5XBU0 24795482 1471 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz E 2.2 BS01 CA E 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz E 2.2 BS02 ZMR E 1 R115 E116 D148 W176 E225 A244 E274 E275 R291 R373 Y408 R40 E41 D73 W101 E150 A169 E199 E200 R216 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM U5XBU0 24795482 1471 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz F 2.2 BS01 CA F 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz F 2.2 BS02 ZMR F 1 R115 E116 D148 R149 W176 R222 E225 E274 R291 R373 Y408 R40 E41 D73 R74 W101 R147 E150 E199 R216 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM U5XBU0 24795482 1470 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz G 2.2 BS01 CA G 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz G 2.2 BS02 ZMR G 1 R115 E116 D148 W176 R222 E225 E274 R291 R373 Y408 R40 E41 D73 W101 R147 E150 E199 R216 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM U5XBU0 24795482 1471 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz H 2.2 BS01 CA H 1 D292 T296 D323 G343 G345 D217 T221 D248 G268 G270 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 U5XBU0 24795482 1466 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL 4cpz H 2.2 BS02 ZMR H 1 R115 E116 D148 W176 E225 E274 R291 R373 Y408 R40 E41 D73 W101 E150 E199 R216 R298 Y333 D148 E275 R291 R373 Y408 D73 E200 R216 R298 Y333 3.2.1.18 0004308,0005975,0016020,0016798,0020002,0033644,0044423,0046872,0052794,0052795,0052796,0055036 Ki=20.85nM U5XBU0 24795482 1470 EPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPNECKHFALTHYAAQPGGYYNGTRGDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNDALLKVKYGEAYTDTYHSYANKLLRTQESACNCIGGNCYLMITDGSASGVSECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTDTYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMESKIGRWYSRTMSKTERMGMGLYVKYDGDPWADSDALAFSGVMVSMKEPGWYSFGFEIKDKECDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL