4cku A 1.85 BS01 P2F A 1 I32 D34 G36 Y77 V78 S79 F111 I123 Y192 D214 G216 T217 S218 I290 I300 I30 D32 G34 Y75 V76 S77 F109 I121 Y190 D212 G214 T215 S216 I284 I294 D34 S37 N39 W41 Y77 D214 T217 D32 S35 N37 W39 Y75 D212 T215 3.4.23.39 0004190,0006508 ic50=0.15uM -logKd/Ki=6.82, IC50=0.15uM IC50=150nM P46925 24900843 400 NDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4cku B 1.85 BS01 P2F B 1 I14 I32 D34 G36 Y77 V78 F111 I123 Y192 D214 G216 T217 S218 F294 I300 I12 I30 D32 G34 Y75 V76 F109 I121 Y190 D212 G214 T215 S216 F292 I298 D34 S37 N39 W41 Y77 D214 T217 D32 S35 N37 W39 Y75 D212 T215 3.4.23.39 0004190,0006508 ic50=0.15uM -logKd/Ki=6.82, IC50=0.15uM IC50=150nM P46925 24900843 400 NDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4cku C 1.85 BS01 P2F C 1 M15 I32 D34 G36 Y77 V78 F111 I123 Y192 D214 G216 S218 L292 I300 M14 I31 D33 G35 Y76 V77 F110 I122 Y191 D213 G215 S217 L285 I293 D34 S37 N39 W41 Y77 D214 T217 D33 S36 N38 W40 Y76 D213 T216 3.4.23.39 0004190,0006508 ic50=0.15uM IC50=150nM P46925 24900843 400 SNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHILCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4cku D 1.85 BS01 P2F D 1 M15 I32 D34 G36 S79 F111 T114 Y192 D214 G216 S218 I300 M14 I31 D33 G35 S78 F110 T113 Y191 D213 G215 S217 I294 D34 S37 N39 W41 Y77 D214 T217 D33 S36 N38 W40 Y76 D213 T216 3.4.23.39 0004190,0006508 ic50=0.15uM IC50=150nM P46925 24900843 400 SNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4cku E 1.85 BS01 P2F E 1 M15 I32 D34 G36 Y77 V78 S79 F111 I123 Y192 D214 G216 T217 S218 I290 L292 I300 M14 I31 D33 G35 Y76 V77 S78 F110 I122 Y191 D213 G215 T216 S217 I283 L285 I293 D34 S37 N39 W41 Y77 D214 T217 D33 S36 N38 W40 Y76 D213 T216 3.4.23.39 0004190,0006508 ic50=0.15uM IC50=150nM P46925 24900843 400 SNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL 4cku F 1.85 BS01 P2F F 1 M15 I32 D34 G36 V78 S79 F111 I123 Y192 D214 G216 T217 S218 I290 L292 M15 I32 D34 G36 V78 S79 F111 I123 Y192 D214 G216 T217 S218 I290 L292 D34 S37 N39 W41 Y77 D214 T217 D34 S37 N39 W41 Y77 D214 T217 3.4.23.39 0004190,0006508 ic50=0.15uM -logKd/Ki=6.82, IC50=0.15uM IC50=150nM P46925 24900843 400 SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL