4cff A 3.924 BS01 STU A 1 L22 G23 G25 V30 A43 K45 E94 Y95 V96 E100 E143 N144 L146 D157 L15 G16 G18 V23 A36 K38 E87 Y88 V89 E93 E136 N137 L139 D150 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff A 3.924 BS02 C1V B 1 L18 G19 K29 K31 I46 D88 L11 G12 K22 K24 I39 D81 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1271 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff B 3.924 BS01 C1V B 1 V81 R83 R107 S108 N111 V113 V4 R6 R30 S31 N34 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 24352254 1271 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCYHQEPYVPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4cff C 3.924 BS01 STU C 1 L22 G23 V24 G25 V30 A43 K45 V96 E100 E143 N144 L146 D157 L13 G14 V15 G16 V21 A34 K36 V87 E91 E134 N135 L137 D148 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff C 3.924 BS02 C1V C 1 G19 K29 K31 I46 D88 G10 K20 K22 I37 D79 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 -logKd/Ki=6.40, Kd=0.40uM P54646 24352254 1553 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff D 3.924 BS01 C1V C 1 S108 V113 S31 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 -logKd/Ki=6.40, Kd=0.40uM Kd=487nM, EC50=390nM Q9Y478 24352254 1553 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCQEPYVCKPPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4cff E 3.924 BS01 AMP E 1 R70 K170 I240 S242 D245 R269 V276 L277 V297 H298 R299 R44 K144 I214 S216 D219 R243 V250 L251 V271 H272 R273 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1326 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4cff E 3.924 BS02 AMP E 2 H151 T200 I204 A205 V225 S226 H298 S314 S316 D317 H125 T174 I178 A179 V199 S200 H272 S288 S290 D291 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1327 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4cff F 3.924 BS01 AMP F 1 R70 K170 I240 S242 D245 R269 V276 L277 V297 H298 R299 R44 K138 I208 S210 D213 R237 V244 L245 V265 H266 R267 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1325 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVL 4cff F 3.924 BS02 AMP F 2 H151 T200 I204 A205 V225 S226 H298 I312 S314 S316 D317 H119 T168 I172 A173 V193 S194 H266 I280 S282 S284 D285 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1326 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVL