4cfe A 3.023 BS01 STU A 1 L22 G23 G25 V30 A43 E94 Y95 V96 E100 E143 N144 L146 D157 L15 G16 G18 V23 A36 E87 Y88 V89 E93 E136 N137 L139 D150 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cfe A 3.023 BS02 992 A 1 L18 G28 K29 K31 I46 N48 D88 L11 G21 K22 K24 I39 N41 D81 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1553 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cfe B 3.023 BS01 992 A 1 R83 V113 R6 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 EC50=2.0nM Q9Y478 24352254 1553 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCEPYVPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4cfe C 3.023 BS01 STU C 1 L22 G25 V30 A43 E94 Y95 V96 E100 E143 N144 L146 D157 L13 G16 V21 A34 E85 Y86 V87 E91 E134 N135 L137 D148 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1552 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDIIDNRRIMNQASEFYLASSPLKPHPERMPPLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cfe C 3.023 BS02 992 C 1 K29 K31 I46 N48 D88 K20 K22 I37 N39 D79 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 -logKd/Ki=7.22, Kd=0.06uM P54646 24352254 1553 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDIIDNRRIMNQASEFYLASSPLKPHPERMPPLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cfe D 3.023 BS01 992 C 1 R83 R107 S108 N111 V113 R6 R30 S31 N34 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 -logKd/Ki=7.22, Kd=0.06uM EC50=2.0nM Q9Y478 24352254 1553 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQEPYVCPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4cfe E 3.023 BS01 AMP E 1 T87 L129 V130 I150 H151 R152 T61 L98 V99 I119 H120 R121 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1326 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4cfe E 3.023 BS02 AMP E 2 K170 I240 S242 F244 D245 R269 L277 V297 H298 R299 K139 I209 S211 F213 D214 R238 L246 V266 H267 R268 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1327 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4cfe E 3.023 BS03 AMP E 3 H151 T200 I204 A205 V225 S226 I312 S314 S316 D317 H120 T169 I173 A174 V194 S195 I281 S283 S285 D286 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1328 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4cfe F 3.023 BS01 AMP F 1 T87 T89 D90 V130 I150 R152 T61 T63 D64 V98 I118 R120 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1326 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4cfe F 3.023 BS02 AMP F 2 K170 I240 S242 D245 R269 V276 L277 V297 H298 R299 K138 I208 S210 D213 R237 V239 L240 V260 H261 R262 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1327 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4cfe F 3.023 BS03 AMP F 3 H151 T200 I204 A205 V225 S226 H298 S314 S316 D317 H119 T168 I172 A173 V193 S194 H261 S277 S279 D280 ? 0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 24352254 1328 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT