4c7j A 2.16 BS01 NAP A 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G16 S18 K19 G20 I21 A40 R41 S42 T67 M68 N94 I96 V143 S145 Y158 K162 L190 G191 L192 I193 T195 T197 A198 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 24422550 1286 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYN 4c7j A 2.16 BS02 4YQ A 1 S170 Y183 G216 L217 A223 D259 S145 Y158 G191 L192 A198 D234 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=9.9nM P28845 24422550 1287 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYN 4c7j B 2.16 BS01 4YQ A 1 Y280 Y284 Y255 Y259 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=9.9nM P28845 24422550 1287 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNMDRFIN 4c7j B 2.16 BS02 NAP B 1 G41 S43 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G16 S18 G20 I21 A40 R41 S42 T67 M68 N94 I96 V143 S145 Y158 K162 L190 G191 L192 I193 T195 T197 A198 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 24422550 1292 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNMDRFIN 4c7j B 2.16 BS03 4YQ B 1 S170 L171 Y177 Y183 G216 L217 A223 A226 M233 D259 S145 L146 Y152 Y158 G191 L192 A198 A201 M208 D234 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=9.9nM P28845 24422550 1293 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNMDRFIN 4c7j C 2.16 BS01 NAP C 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S169 S170 Y183 K187 L215 G216 I218 T220 T222 A223 G16 S18 K19 G20 I21 A40 R41 S42 T67 M68 N94 I96 V143 S144 S145 Y158 K162 L190 G191 I193 T195 T197 A198 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 24422550 1282 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYS 4c7j C 2.16 BS02 4YQ C 1 L126 S170 Y177 Y183 G216 L217 D259 L101 S145 Y152 Y158 G191 L192 D234 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=9.9nM P28845 24422550 1283 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYS 4c7j D 2.16 BS01 NAP D 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G16 S18 K19 G20 I21 A40 R41 S42 T67 M68 N94 I96 V143 S145 Y158 K162 L190 G191 L192 I193 T195 T197 A198 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 24422550 1283 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYST 4c7j D 2.16 BS02 4YQ D 1 S170 Y177 Y183 G216 L217 A226 D259 S145 Y152 Y158 G191 L192 A201 D231 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=9.9nM P28845 24422550 1284 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYST