4bo0 A 2.4 BS01 FXE A 1 W106 V110 L114 A156 G160 W94 V98 L102 A144 G148 G16 S141 Y154 K158 G17 S129 Y142 K146 1.1.1.100 0004316,0006633,0016491,0016616,0030497,0050661,0051287 ic50=0.2uM -logKd/Ki=6.70, IC50=0.20uM O54438 24015914 1248 SMSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGSVVGAMGNAGQTNYAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS 4bo0 B 2.4 BS01 FXE A 1 F107 L114 A156 G160 G163 F164 F97 L104 A146 G150 G153 F154 G16 S141 Y154 K158 G17 S131 Y144 K148 1.1.1.100 0004316,0006633,0016491,0016616,0030497,0050661,0051287 -logKd/Ki=6.70, IC50=0.20uM O54438 24015914 1248 SMSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGIDEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGSVVGAMGNAGQTNYAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS 4bo0 C 2.4 BS01 FXE C 1 W106 V110 N111 L114 A156 G160 F164 W109 V113 N114 L117 A153 G157 F161 G16 S141 Y154 K158 G28 S144 Y151 K155 1.1.1.100 0004316,0006633,0016491,0016616,0030497,0050661,0051287 ic50=0.2uM O54438 24015914 1248 HHHHHSSLYFQSMSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGSVVGQTNYAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS 4bo0 D 2.4 BS01 FXE C 1 V110 L114 G163 F164 V104 L108 G157 F158 G16 S141 Y154 K158 G17 S135 Y148 K152 1.1.1.100 0004316,0006633,0016491,0016616,0030497,0050661,0051287 O54438 24015914 1248 SMSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGIRMKDDEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGSVVGAMGNAGQTNYAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS