4bbe A 1.9 BS01 3O4 A 1 L855 F860 V863 K882 E930 Y931 L932 G935 L983 D994 L15 F20 V23 K42 E90 Y91 L92 G95 L143 D154 N976 A978 R980 N981 D994 S1016 N136 A138 R140 N141 D154 S176 2.7.10.2 0004672,0005524,0006468 ic50=3.6nM -logKd/Ki=8.44, IC50=3.6nM IC50=974.7nM O60674 23127890 2229 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRNLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRD 4bbe B 1.9 BS01 3O4 B 1 L855 G856 V863 Y931 L932 G935 L983 L15 G16 V23 Y91 L92 G95 L143 N976 A978 R980 N981 D994 S1016 N136 A138 R140 N141 D154 S176 2.7.10.2 0004672,0005524,0006468 ic50=3.6nM IC50=974.7nM O60674 23127890 2229 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRNLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRD 4bbe C 1.9 BS01 3O4 C 1 L855 V863 K882 M929 Y931 L932 G935 L15 V23 K42 M89 Y91 L92 G95 N976 A978 R980 N981 D994 S1016 N136 A138 R140 N141 D154 S176 2.7.10.2 0004672,0005524,0006468 ic50=3.6nM IC50=974.7nM O60674 23127890 2229 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRNLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRD 4bbe D 1.9 BS01 3O4 D 1 L855 F860 V863 K882 Y931 L932 G935 L983 D994 L15 F20 V23 K42 Y91 L92 G95 L143 D154 N976 A978 R980 N981 D994 S1016 N136 A138 R140 N141 D154 S176 2.7.10.2 0004672,0005524,0006468 ic50=3.6nM IC50=974.7nM O60674 23127890 2229 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRNLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRD