4b13 A 1.58 BS01 X25 A 1 V96 E97 D98 F103 F105 Y211 Y315 S319 Y334 L367 L388 L410 V71 E72 D73 F78 F80 Y186 Y290 S294 Y309 L342 L363 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 ic50=2uM -logKd/Ki=5.70, IC50=2.0uM A5K1A2 23035716 1411 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 A 1.58 BS02 NHW A 1 Y28 F30 W31 Y95 V96 N161 L163 C164 V165 R170 S171 R173 A175 P176 I179 T183 I186 W192 Q193 A194 Y196 T197 A198 L202 Y393 Y3 F5 W6 Y70 V71 N136 L138 C139 V140 R145 S146 R148 A150 P151 I154 T158 I161 W167 Q168 A169 Y171 T172 A173 L177 Y368 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1412 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 A 1.58 BS03 MG A 1 S171 K172 L174 S146 K147 L149 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1414 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 B 1.58 BS01 X25 B 1 E97 D98 F105 Y211 Y315 Y334 L367 L410 E72 D73 F80 Y186 Y290 Y309 L342 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 ic50=2uM A5K1A2 23035716 1411 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 B 1.58 BS02 NHW B 1 Y28 F30 W31 Y95 V96 V160 N161 L163 C164 V165 R170 S171 R173 L174 A175 P176 I179 I186 W192 A194 Y196 T197 L202 Y393 Y3 F5 W6 Y70 V71 V135 N136 L138 C139 V140 R145 S146 R148 L149 A150 P151 I154 I161 W167 A169 Y171 T172 L177 Y368 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1412 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 B 1.58 BS03 MG B 1 S171 K172 L174 S146 K147 L149 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1415 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 C 1.58 BS01 X25 C 1 E97 D98 F105 Y211 Y315 S319 Y334 L367 L388 L410 E72 D73 F80 Y186 Y273 S277 Y292 L325 L346 L368 N161 F162 L163 T197 L410 N136 F137 L138 T172 L368 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 ic50=2uM A5K1A2 23035716 1411 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 C 1.58 BS02 NHW C 1 Y28 F30 W31 Y95 V96 N161 L163 C164 V165 R170 S171 R173 A175 T183 I186 W192 A194 Y196 T197 A198 L202 Y393 Y3 F5 W6 Y70 V71 N136 L138 C139 V140 R145 S146 R148 A150 T158 I161 W167 A169 Y171 T172 A173 L177 Y351 N161 F162 L163 T197 L410 N136 F137 L138 T172 L368 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1412 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b13 C 1.58 BS03 MG C 1 L169 S171 K172 L174 L144 S146 K147 L149 N161 F162 L163 T197 L410 N136 F137 L138 T172 L368 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1414 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL