4b12 A 1.79 BS01 C23 A 1 E97 D98 F103 F105 Y211 Y315 S319 Y334 L367 L388 L410 E72 D73 F78 F80 Y186 Y290 S294 Y309 L342 L363 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 ic50=10.2uM -logKd/Ki=4.99, IC50=10.2uM A5K1A2 23035716 1411 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 A 1.79 BS02 NHW A 1 Y28 F30 W31 Y95 V96 V160 L163 V165 R170 S171 R173 A175 T183 I186 W192 Q193 A194 Y196 T197 A198 L202 Y393 Y3 F5 W6 Y70 V71 V135 L138 V140 R145 S146 R148 A150 T158 I161 W167 Q168 A169 Y171 T172 A173 L177 Y368 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1412 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 A 1.79 BS03 MG A 1 K172 L174 K147 L149 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1417 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 B 1.79 BS01 C23 B 1 V96 E97 D98 F105 Y107 Y211 H213 Y334 L367 L410 V71 E72 D73 F80 Y82 Y186 H188 Y309 L342 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 ic50=10.2uM A5K1A2 23035716 1411 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 B 1.79 BS02 NHW B 1 Y28 F30 W31 Y95 V96 N161 L163 V165 R170 S171 R173 A175 P176 T183 I186 W192 Q193 Y196 T197 A198 L202 Y393 Y3 F5 W6 Y70 V71 N136 L138 V140 R145 S146 R148 A150 P151 T158 I161 W167 Q168 Y171 T172 A173 L177 Y368 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1412 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 B 1.79 BS03 MG B 1 K172 L174 K147 L149 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1418 MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 C 1.79 BS01 C23 C 1 E97 D98 F103 F105 Y107 Y211 S319 Y334 L367 L410 E71 D72 F77 F79 Y81 Y185 S277 Y292 L325 L368 N161 F162 L163 T197 L410 N135 F136 L137 T171 L368 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 ic50=10.2uM A5K1A2 23035716 1411 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 C 1.79 BS02 NHW C 1 Y28 F30 W31 Y95 V96 L163 C164 V165 R170 S171 R173 A175 I179 T183 I186 W192 Q193 A194 Y196 T197 A198 L202 Y393 Y2 F4 W5 Y69 V70 L137 C138 V139 R144 S145 R147 A149 I153 T157 I160 W166 Q167 A168 Y170 T171 A172 L176 Y351 N161 F162 L163 T197 L410 N135 F136 L137 T171 L368 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1412 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 4b12 C 1.79 BS03 MG C 1 L169 S171 K172 L174 L143 S145 K146 L148 N161 F162 L163 T197 L410 N135 F136 L137 T171 L368 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 23035716 1416 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL