4aze A 3.15 BS01 3RA A 1 I165 F170 A186 K188 L241 L294 D307 I34 F39 A55 K57 L110 L163 D176 D287 K289 N292 D307 S324 D156 K158 N161 D176 S193 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 -logKd/Ki=8.11, Kd=7.8nM IC50=7.6nM Q13627 22998443 700 ERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK 4aze B 3.15 BS01 peptide G 0 E366 V367 K393 E232 V233 K259 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 22998443 899 ~ 902 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK 4aze B 3.15 BS02 3RA B 1 F170 A186 K188 L241 N244 L294 D307 F36 A52 K54 L107 N110 L160 D173 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=7.6nM Q13627 22998443 700 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK 4aze C 3.15 BS01 3RA C 1 I165 F170 A186 K188 F238 L241 L294 D307 I34 F39 A55 K57 F107 L110 L163 D176 D287 K289 N292 D307 S324 D156 K158 N161 D176 S193 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=7.6nM Q13627 22998443 700 ERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK