4ayu A 1.5 BS01 CA A 1 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 205 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu A 1.5 BS02 CA A 2 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 206 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu A 1.5 BS03 N8P A 1 N59 L62 Y64 Y74 E136 Q148 N59 L62 Y64 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 Kd=18.6uM -logKd/Ki=4.73, Kd=18.6uM P02743 25084341 499 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu B 1.5 BS01 CA B 1 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 205 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu B 1.5 BS02 CA B 2 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 206 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu B 1.5 BS03 N8P B 1 N59 L62 Y64 Y74 E136 Q148 N59 L62 Y64 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 Kd=18.6uM P02743 25084341 499 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu C 1.5 BS01 CA C 1 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 205 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu C 1.5 BS02 CA C 2 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 206 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu C 1.5 BS03 N8P C 1 N59 L62 Y64 Y74 E136 Q148 N59 L62 Y64 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 Kd=18.6uM P02743 25084341 499 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu D 1.5 BS01 CA D 1 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 205 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu D 1.5 BS02 CA D 2 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 206 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu D 1.5 BS03 N8P D 1 N59 L62 Y64 Y74 E136 Q148 N59 L62 Y64 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 Kd=18.6uM P02743 25084341 499 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu E 1.5 BS01 CA E 1 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 205 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu E 1.5 BS02 CA E 2 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 25084341 206 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 4ayu E 1.5 BS03 N8P E 1 N59 L62 Y64 Y74 E136 Q148 N59 L62 Y64 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 Kd=18.6uM P02743 25084341 499 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV