4app A 2.2 BS01 N53 A 1 G330 G333 V335 A348 K350 E396 F397 L398 G401 D405 L447 D458 R586 T590 G32 G35 V37 A50 K52 E98 F99 L100 G103 D107 L149 D160 R288 T292 D440 K442 D444 S445 D458 K467 T478 D142 K144 D146 S147 D160 K169 T180 2.7.11.1 0004672,0005524,0006468 Ki=0.064uM -logKd/Ki=7.19, Ki=0.064uM Ki=64nM, EC50=810nM O96013 22554206 601 MSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT