4an3 A 2.1 BS01 MG A 1 N195 D208 N138 D151 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T167 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 1382 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4an3 A 2.1 BS02 ATP A 1 L74 G77 N78 A95 K97 M143 M146 S150 Q153 K192 S194 L197 L17 G20 N21 A38 K40 M86 M89 S93 Q96 K135 S137 L140 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T167 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 1383 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4an3 A 2.1 BS03 5Y0 A 1 K97 V127 I141 D208 F209 V211 L215 K40 V70 I84 D151 F152 V154 L158 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T167 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=9.22, IC50=0.6nM Q02750 24900486 1384 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL