4afj A 1.98 BS01 peptide X 0 Y216 I228 F229 G262 V263 V267 T275 Y288 E290 K292 F293 Y176 I188 F189 G222 V223 V227 T235 Y248 E250 K252 F253 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 22310227 200 ~ 222 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 4afj A 1.98 BS02 SJJ A 1 F67 A83 Y134 V135 P136 L188 D200 F32 A48 Y94 V95 P96 L148 D160 D181 K183 N186 D200 S219 D141 K143 N146 D160 S179 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=398nM -logKd/Ki=6.40, IC50=398nM IC50=1995nM P49841 22310227 1391 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 4afj B 1.98 BS01 peptide Y 0 I228 F229 V263 L266 V267 I270 T275 Y288 E290 F291 K292 F293 P294 I296 I191 F192 V226 L229 V230 I233 T238 Y251 E253 F254 K255 F256 P257 I259 D181 K183 N186 D200 S219 D144 K146 N149 D163 S182 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 22310227 200 ~ 222 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 4afj B 1.98 BS02 SJJ B 1 F67 A83 K85 Y134 V135 P136 L188 C199 D200 F34 A50 K52 Y97 V98 P99 L151 C162 D163 D181 K183 N186 D200 S219 D144 K146 N149 D163 S182 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=398nM IC50=1995nM P49841 22310227 1392 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI