4ach A 2.6 BS01 KDI A 1 I62 A83 D133 Y134 V135 P136 R141 L188 C199 I28 A49 D99 Y100 V101 P102 R107 L154 C165 D181 K183 N186 D200 S219 D147 K149 N152 D166 S185 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 -logKd/Ki=7.66, Ki=22nM Ki=22nM P49841 22489897 1386 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 4ach B 2.6 BS01 KDI B 1 I62 A83 D133 Y134 V135 P136 R141 L188 C199 I28 A49 D99 Y100 V101 P102 R107 L154 C165 D181 K183 N186 D200 S219 D147 K149 N152 D166 S185 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 Ki=22nM P49841 22489897 1386 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI