4acg A 2.6 BS01 6LQ A 1 I62 A83 K85 Y134 V135 P136 R141 Q185 N186 L188 C199 D200 I28 A49 K51 Y100 V101 P102 R107 Q151 N152 L154 C165 D166 D181 K183 N186 D200 S219 D147 K149 N152 D166 S185 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 -logKd/Ki=9.66, Ki=0.22nM P49841 22489897 1385 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 4acg B 2.6 BS01 6LQ B 1 I62 F67 A83 K85 Y134 V135 P136 R141 Q185 N186 L188 C199 D200 I28 F33 A49 K51 Y100 V101 P102 R107 Q151 N152 L154 C165 D166 D181 K183 N186 D200 S219 D147 K149 N152 D166 S185 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 P49841 22489897 1385 SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI